caa a22 4500 469121289 CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02245408 doi (NATIONALLICENCE)springer-10.1007/BF02245408 Behavioral analysis of diazepam-induced memory deficits: evidence for sedation-like effects [Elektronische Daten] [Lisa Kalynchuk, Charles Beck] Rats were trained on a nonmatching-to-sample task with delays of 2, 5, and 10 min. Subsequently, performance was assessed in three groups of rats following treatment with saline or diazepam (2.0 mg/kg) administered acutely or tested chronically in six administrations. Relative to treatment with saline, diazepam produced a deficit in discrimination performance, which was greater in the acutely treated rats than in those treated chronically. The deficit was not dependent on the length of the delays. Diazepam-treated animals differed from controls in erring on trials in which they failed to investigate both test objects, failed to investigate the test object for a long enough period of time, and displaced the test object on the preferred side of the apparatus. The hypothesis that these effects represented a sedation-like reduction in behavioral variability was also supported by evidence of a diazepam-induced decrease in gross bodily activity, increase in inactivity, and increase in latencies to respond to objects. No support was found for the involvement of diazepam-induced changes in habituation, extinction, or reward effects. Springer-Verlag, 1992 Diazepam nationallicence Benzodiazepine nationallicence Delay-dependent memory nationallicence Behavioral variability nationallicence Sedation nationallicence Rat nationallicence Kalynchuk Lisa Department of Psychology, Bioscience Building, University of Alberta, T6G 2E9, Edmonton, Canada aut Beck Charles Department of Psychology, Bioscience Building, University of Alberta, T6G 2E9, Edmonton, Canada aut Psychopharmacology Springer-Verlag 106/3(1992-03-01), 297-302 0033-3158 106:3<297 1992 106 213 https://doi.org/10.1007/BF02245408 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245408 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kalynchuk Lisa Department of Psychology, Bioscience Building, University of Alberta, T6G 2E9, Edmonton, Canada aut NATIONALLICENCE 700 1- Beck Charles Department of Psychology, Bioscience Building, University of Alberta, T6G 2E9, Edmonton, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/3(1992-03-01), 297-302 0033-3158 106:3<297 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer