caa a22 4500 469121300 CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02245412 doi (NATIONALLICENCE)springer-10.1007/BF02245412 Fluoxetine decreases brain temperature and REM sleep in Syrian hamsters [Elektronische Daten] [Bo Gao, Wallace Duncan Jr, Thomas Wehr] The antidepressant drug, fluoxetine (FLX), a selective serotonin reuptake inhibitor, was administered to Syrian hamsters, and its acute and chronic effects on EEG sleep and hypothalamic temperature were recorded. Acute fluoxetine treatment at doses of 5, 10, 20 and 40 mg/kg decreased REM sleep and hypothalamic temperature in a dose-dependent manner. It increased NREM sleep, and, at doses of 20 and 40 mg/kg, it increased wakefulness. At 40 mg/kg, it decreased motor activity. During chronic treatment, tolerance developed to FLX's REM sleep-inhibiting effects, but tolerance did not develop to FLX's hypothalamic temperature-decreasing effects. Chronic FLX treatment produced circadian phase-dependent decreases in temperature beyond those that were observed during acute treatment. The apparent dissociation during chronic treatment between FLX's temperature-lowering effects and its REM-decreasing effects might be related to long-term changes in 5HT receptor function or FLX pharmacokinetics. Springer-Verlag, 1992 Fluoxetine nationallicence REM sleep nationallicence Hypothalamic temperature nationallicence Syrian hamster nationallicence Serotonin nationallicence Gao Bo Clinical Psychobiology Branch, National Institute of Mental Health, 20892, Bethesda, MD, USA aut Duncan Jr Wallace Clinical Psychobiology Branch, National Institute of Mental Health, 20892, Bethesda, MD, USA aut Wehr Thomas Clinical Psychobiology Branch, National Institute of Mental Health, 20892, Bethesda, MD, USA aut Psychopharmacology Springer-Verlag 106/3(1992-03-01), 321-329 0033-3158 106:3<321 1992 106 213 https://doi.org/10.1007/BF02245412 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245412 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gao Bo Clinical Psychobiology Branch, National Institute of Mental Health, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Duncan Jr Wallace Clinical Psychobiology Branch, National Institute of Mental Health, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Wehr Thomas Clinical Psychobiology Branch, National Institute of Mental Health, 20892, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/3(1992-03-01), 321-329 0033-3158 106:3<321 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer