caa a22 4500 469121327 CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02245428 doi (NATIONALLICENCE)springer-10.1007/BF02245428 Antinociceptive effect of chronic nicotine and nociceptive effect of its withdrawal measured by hot-plate and tail-flick in rats [Elektronische Daten] [Ching-Yue Yang, Wen-Hsien Wu, Vlasta Zbuzek] Nicotine (6 mg/kg/day) was administered subcutaneously via Alzet osmotic pumps to rats for 28 days. Nociception was measured by the hot-plate and tail-flick methods. A significant antinociceptive effect was demonstrated during the first week of the treatment; after that tolerance developed, lasting for the remaining period of nicotine treatment. This effect was more pronounced in the habituated, rather than in the naive, rats. Rats subjected to nicotine withdrawal tended to exhibit the nociceptive effect for 10 days with an overallP value on the border of significance. This chronic nicotine-induced antinociception and nicotine withdrawal-induced nociception was detectable only by hot-plate but not the tail-flick technique. Springer-Verlag, 1992 Chronic nicotine nationallicence Withdrawal nationallicence Antinociception nationallicence Nociception nationallicence Hot-plate nationallicence Tail-flick nationallicence Rats nationallicence Yang Ching-Yue Department of Anesthesiology, UMD-New Jersey Medical School, 185 South Orange Avenue, 07103-2757, Newark, NJ, USA aut Wu Wen-Hsien Department of Anesthesiology, UMD-New Jersey Medical School, 185 South Orange Avenue, 07103-2757, Newark, NJ, USA aut Zbuzek Vlasta Department of Anesthesiology, UMD-New Jersey Medical School, 185 South Orange Avenue, 07103-2757, Newark, NJ, USA aut Psychopharmacology Springer-Verlag 106/3(1992-03-01), 417-420 0033-3158 106:3<417 1992 106 213 https://doi.org/10.1007/BF02245428 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245428 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Ching-Yue Department of Anesthesiology, UMD-New Jersey Medical School, 185 South Orange Avenue, 07103-2757, Newark, NJ, USA aut NATIONALLICENCE 700 1- Wu Wen-Hsien Department of Anesthesiology, UMD-New Jersey Medical School, 185 South Orange Avenue, 07103-2757, Newark, NJ, USA aut NATIONALLICENCE 700 1- Zbuzek Vlasta Department of Anesthesiology, UMD-New Jersey Medical School, 185 South Orange Avenue, 07103-2757, Newark, NJ, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/3(1992-03-01), 417-420 0033-3158 106:3<417 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer