caa a22 4500 469121335 CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02245410 doi (NATIONALLICENCE)springer-10.1007/BF02245410 Serotonin but not norepinephrine-induced calcium mobilization of platelets is enhanced in affective disorders [Elektronische Daten] [Masahiko Mikuni, Ariyuki Kagaya, Kiyohisa Takahashi, Herbert Meltzer] Intracellular calcium concentrations ([Ca++]i) in blood platelets from 11 depressed patients and 11 healthy controls were investigated. The resting [Ca++]i of platelets from depressed patients was 69.4±2.9 nM while that from controls was 74.6±4.0 nM. Serotonin (5-HT), at a concentration of 10 µM, increased [Ca++]i by 129.2±3.9 nM in platelets from depressed patients, which was significantly greater than that found in platelets from control subjects (105.2±6.0 nM). Norepinephrine (NE) 100 µM increased [Ca++]i by 46.1±7.1 nM in platelets from depressed patients, and by 38.6±6.1 nM in platelets from controls, respectively. These results indicate that 5-HT2 receptor function in platelets of depressed patients is enhanced, and support the hypothesis of hypersensitivity of 5-HT2 receptors in affective disorders. Springer-Verlag, 1992 Depression nationallicence Platelets nationallicence Calcium nationallicence Serotonin nationallicence Mikuni Masahiko Division of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, 187, Kodaira Tokyo, Japan aut Kagaya Ariyuki Division of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, 187, Kodaira Tokyo, Japan aut Takahashi Kiyohisa Division of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, 187, Kodaira Tokyo, Japan aut Meltzer Herbert Laboratory of Biological Psychiatry, Case Western Reserve University, School of Medicine, 2040, Abington Road, 44106, Cleveland, OH, USA aut Psychopharmacology Springer-Verlag 106/3(1992-03-01), 311-314 0033-3158 106:3<311 1992 106 213 https://doi.org/10.1007/BF02245410 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245410 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mikuni Masahiko Division of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, 187, Kodaira Tokyo, Japan aut NATIONALLICENCE 700 1- Kagaya Ariyuki Division of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, 187, Kodaira Tokyo, Japan aut NATIONALLICENCE 700 1- Takahashi Kiyohisa Division of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, 187, Kodaira Tokyo, Japan aut NATIONALLICENCE 700 1- Meltzer Herbert Laboratory of Biological Psychiatry, Case Western Reserve University, School of Medicine, 2040, Abington Road, 44106, Cleveland, OH, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/3(1992-03-01), 311-314 0033-3158 106:3<311 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer