caa a22 4500 469121343 CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02245430 doi (NATIONALLICENCE)springer-10.1007/BF02245430 Effect of pindolol on endocrine and temperature responses to buspirone in healthy volunteers [Elektronische Daten] [I. Anderson, P. Cowen] Ten healthy subjects received buspirone (30 mg orally) with and without pre-treatment with the 5-HT1A receptor antagonist, pindolol (80 mg over 3 days). Following pindolol treatment the growth hormone and hypothermic responses to buspirone were significantly decreased. There was also a delay in the onset of the prolactin response to buspirone but the total amount of prolactin secretion, calculated as area under the curve, was not significantly reduced. The data suggest that the growth hormone and hypothermic responses to buspirone in humans are mediated by 5-HT1A receptors, but an explanation founded on pharmacokinetic factors cannot presently be excluded. Both this latter possibility and the lack of selectivity of pindolol for 5-HT receptors indicate the need for the further neuroendocrine studies of the mode of action of buspirone, preferably with more selective 5-HT1A receptor antagonists. Springer-Verlag, 1992 Buspirone nationallicence Growth hormone nationallicence Prolactin nationallicence Pindolol nationallicence Hypothermia nationallicence 5-HT1A receptor nationallicence Anderson I. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut Cowen P. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut Psychopharmacology Springer-Verlag 106/3(1992-03-01), 428-432 0033-3158 106:3<428 1992 106 213 https://doi.org/10.1007/BF02245430 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245430 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Anderson I. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut NATIONALLICENCE 700 1- Cowen P. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/3(1992-03-01), 428-432 0033-3158 106:3<428 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer