caa a22 4500 469121351 CHVBK 20180323133140.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02245411 doi (NATIONALLICENCE)springer-10.1007/BF02245411 Effect of the 5-HT3 receptor antagonists, MDL72222 and ondansetron on morphine place conditioning [Elektronische Daten] [Guy Higgins, Narges Joharchi, Peter Nguyen, Edward Sellers] The purpose of the present study was to reassess the original findings of Carboni et al. (1988) who suggested that 5-HT3 receptor antagonists may block morphine-induced place conditioning in rats. These workers used a biased protocol with treatments allocated to compartments based on initial preference. In the present study we have adopted an unbiased approach with treatments randomly assigned to conditioning compartment in a counter-balanced fashion. Thus treatments were equally paired between distinct environmental cues. Using this protocol, morphine produced a dose-related place preference (0.3-3 mg/kg SC). Thirty-minute pretreatment with the selective 5-HT3 antagonists, MDL72222 (1 mg/kg SC) and ondansetron (0.01 mg/kg SC) before morphine (1.5 mg/kg SC), significantly antagonized the place conditioning to this treatment. However, with higher doses of ondansetron (0.1-1 mg/kg SC), the antagonism of morphine-induced place preference became variable and dependent on the conditioning compartment. This was probably a reflection of the fact that ondansetron when administered alone also appeared to produce an environmentally dependent place conditioning at these doses. Therefore it is concluded that at certain doses, 5-HT3 receptor antagonists may antagonize morphine place conditioning in a manner consistent with a blockade of the appetitive effects of this drug. However, at higher doses, at least with ondansetron, this antagonism became non-specific and dependent on the training environment. It is suggested that other animal models of opioid reinforcement (e.g., self-administration) are now needed to validate the hypothesis that 5-HT3 receptor antagonists may modify opioid reward. Springer-Verlag, 1992 Morphine nationallicence 5-HT3 receptor nationallicence Ondansetron nationallicence MDL72222 nationallicence Rat nationallicence Place conditioning nationallicence Reward nationallicence Higgins Guy Clinical Psychopharmacology Program, Addiction Research Foundation and Departments of Pharmacology and Medicine, University of Toronto, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut Joharchi Narges Clinical Psychopharmacology Program, Addiction Research Foundation and Departments of Pharmacology and Medicine, University of Toronto, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut Nguyen Peter Clinical Psychopharmacology Program, Addiction Research Foundation and Departments of Pharmacology and Medicine, University of Toronto, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut Sellers Edward Clinical Psychopharmacology Program, Addiction Research Foundation and Departments of Pharmacology and Medicine, University of Toronto, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut Psychopharmacology Springer-Verlag 106/3(1992-03-01), 315-320 0033-3158 106:3<315 1992 106 213 https://doi.org/10.1007/BF02245411 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245411 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Higgins Guy Clinical Psychopharmacology Program, Addiction Research Foundation and Departments of Pharmacology and Medicine, University of Toronto, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Joharchi Narges Clinical Psychopharmacology Program, Addiction Research Foundation and Departments of Pharmacology and Medicine, University of Toronto, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Nguyen Peter Clinical Psychopharmacology Program, Addiction Research Foundation and Departments of Pharmacology and Medicine, University of Toronto, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Sellers Edward Clinical Psychopharmacology Program, Addiction Research Foundation and Departments of Pharmacology and Medicine, University of Toronto, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/3(1992-03-01), 315-320 0033-3158 106:3<315 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer