caa a22 4500 469121408 CHVBK 20180323133140.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02245407 doi (NATIONALLICENCE)springer-10.1007/BF02245407 Chang Wen-Ho Laboratory of Biological Psychiatry, Taipei City Psychiatric Center, 309 Sung-Te Road, Taipei, Taiwan 10510, Republic of China aut Reduced haloperidol: a factor in determining the therapeutic benefit of haloperidol treatment? [Elektronische Daten] [Wen-Ho Chang] One of the metabolic pathways of haloperidol (HAL) is the reduction of the molecule at the benzylic ketone to form an alcohol metabolite, known as reduced HAL (RHAL). The basic and clinical pharmacology of RHAL is the subject of this review. The investigation of RHAL in biological samples has been suggested to be important, as the reduced metabolite can be reconverted back to the parent drug and is shown to be 20-50% as potent as HAL in some in vivo neuroleptic tests. Nevertheless, the metabolic reduction/oxidation cycle of the drug is unbalanced. The interconversion process largely favours the reduction of HAL to RHAL but not vice versa. The RHAL/HAL ratios are dose and time dependent. The higher the dose or the longer the duration of treatment, the greater the ratio. The results concerning relationship between plasma RHAL level or RHAL/HAL ratio and clinical response are inconsistent, yet interesting. Some studies in schizophrenic patients have suggested a diminished therapeutic response to HAL when elevated plasma RHAL concentrations or RHAL/HAL ratios are presented. However, this finding has not been replicated by other investigations. Possible interference by RHAL with HAL at dopamine receptors thus reducing the effectiveness of HAL treatment has been suggested by some authors. Measurements of RHAL as well as HAL plasma concentrations for evaluating drug level-clinical response might be necessary in psychiatric patients. Springer-Verlag, 1992 Reduced haloperidol nationallicence Haloperidol nationallicence Plasma concentrations nationallicence Drug metabolism nationallicence Pharmacokinetics nationallicence Schizophrenia nationallicence Psychopharmacology Springer-Verlag 106/3(1992-03-01), 289-296 0033-3158 106:3<289 1992 106 213 https://doi.org/10.1007/BF02245407 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245407 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Chang Wen-Ho Laboratory of Biological Psychiatry, Taipei City Psychiatric Center, 309 Sung-Te Road, Taipei, Taiwan 10510, Republic of China aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/3(1992-03-01), 289-296 0033-3158 106:3<289 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer