caa a22 4500 469121432 CHVBK 20180323133140.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF02246253 doi (NATIONALLICENCE)springer-10.1007/BF02246253 A double-blind comparison of moclobemide and toloxatone in out-patients presenting a major depressive disorder [Elektronische Daten] [P. Lemoine, C. Mirabaud] A double-blind comparison of moclobemide and toloxatone was performed in adult out-patients diagnosed as suffering from a major depressive disorder. Parallel groups of patients received moclobemide, 450 mg/day (n=135) or toloxatone, 1000 mg/day (n=133) for 28 days. Both groups showed a significant clinical improvement while on therapy; the response was most marked and rapid in those receiving moclobemide treatment. Improvement was greatest in those patients with the most severe depression at the time of trial onset. A significantly higher number of patients returned to normal sleep patterns following moclobemide treatment than following toloxatone. Overall, tolerance was rated as good or very good in more than 80% of patients. The most frequent complaints in the moclobemide-treated group were hot flushes, dry mouth, constipation and headache, while an increase in anxiety was associated with toloxatone usage. Moclobemide was found to be as effective as toloxatone in the treatment of major depressive episodes, but with the advantages of improved sleep patterns and reduced anxiety. Springer-Verlag, 1992 Moclobemide nationallicence Toloxatone nationallicence Out-patients nationallicence Major depressive disorder nationallicence Lemoine P. CHS du Vinatier, 95 Boulevard Pinel, F-69677, Bron Cedex, France aut Mirabaud C. Produits Roche SA, 52 Boulevard du Parc, F-92521, Neuilly-s/Seine Cedex, France aut Psychopharmacology Springer-Verlag 106(1992-02-01), S118-S119 0033-3158 106<S118 1992 106 213 https://doi.org/10.1007/BF02246253 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02246253 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lemoine P. CHS du Vinatier, 95 Boulevard Pinel, F-69677, Bron Cedex, France aut NATIONALLICENCE 700 1- Mirabaud C. Produits Roche SA, 52 Boulevard du Parc, F-92521, Neuilly-s/Seine Cedex, France aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106(1992-02-01), S118-S119 0033-3158 106<S118 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer