caa a22 4500 469121467 CHVBK 20180323133140.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF02246233 doi (NATIONALLICENCE)springer-10.1007/BF02246233 Influence of moclobemide on ibuprofen-induced faecal blood loss [Elektronische Daten] [T. Güntert, M. Schmitt, J. Dingemanse, J. Jonkman] In a pharmacological screen on drug-drug interactions performed in laboratory animals moclobemide potentiated at high doses the antiphlogistic/anti-inflammatory activity of ibuprofen. Therefore, a study was undertaken to determine in healthy volunteers the faecal blood loss induced by multiple doses of ibuprofen (600 mg t.i.d.) in presence and absence of steady-state concentrations of concomitantly administered moclobemide (150 mg t.i.d.). The results show that multiple doses of moclobemide do not change faecal blood loss induced by ibuprofen. Furthermore, no clinically relevant pharmacokinetic interaction between the two drugs studied was detected. Springer-Verlag, 1992 Moclobemide nationallicence Ibuprofen nationallicence Interaction nationallicence Pharmacokinetics nationallicence Pharmacodynamics nationallicence Güntert T. Department of Clinical Pharmacology, F. Hoffmann-La Roche Ltd, CH-4002, Basel, Switzerland aut Schmitt M. Department of Clinical Pharmacology, F. Hoffmann-La Roche Ltd, CH-4002, Basel, Switzerland aut Dingemanse J. Department of Clinical Pharmacology, F. Hoffmann-La Roche Ltd, CH-4002, Basel, Switzerland aut Jonkman J. Pharma Bio-Research Int. B.V., NL-9471 GP, Zuidlaren, The Netherlands aut Psychopharmacology Springer-Verlag 106(1992-02-01), S40-S42 0033-3158 106<S40 1992 106 213 https://doi.org/10.1007/BF02246233 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02246233 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Güntert T. Department of Clinical Pharmacology, F. Hoffmann-La Roche Ltd, CH-4002, Basel, Switzerland aut NATIONALLICENCE 700 1- Schmitt M. Department of Clinical Pharmacology, F. Hoffmann-La Roche Ltd, CH-4002, Basel, Switzerland aut NATIONALLICENCE 700 1- Dingemanse J. Department of Clinical Pharmacology, F. Hoffmann-La Roche Ltd, CH-4002, Basel, Switzerland aut NATIONALLICENCE 700 1- Jonkman J. Pharma Bio-Research Int. B.V., NL-9471 GP, Zuidlaren, The Netherlands aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106(1992-02-01), S40-S42 0033-3158 106<S40 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer