caa a22 4500 469121637 CHVBK 20180323133140.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF02246237 doi (NATIONALLICENCE)springer-10.1007/BF02246237 Antidepressants and cognition: comparative effects of moclobemide, viloxazine and maprotiline [Elektronische Daten] [H. Allain, A. Lieury, F. Brunet-Bourgin, C. Mirabaud, P. Trebon, F. Le Coz, J. Gandon] The respective effects of three antidepressant drugs (moclobemide, 450 mg/j; viloxazine, 300 mg/j; maprotiline, 150 mg/j) on vigilance, attention, and memory were compared. Young depressed outpatients (n=46) entered a double-blind, randomised, monocentre clinical trial lasting for 6 weeks. Drug actions were assessed through the regular determination of critical flicker fusion point (CFF), reaction times (SRT), and a battery to measure memory components. None of the three drugs caused deterioration in cognitive functions. On the other hand, moclobemide improved both vigilance and attention (CFF, SRT) and some crucial components of memory (general memory scores, delayed word recall, recognition of familiar faces). This effect was rapid, stable, and superior to those of viloxazine and maprotiline. It may be explained by moclobemide's selective and reversible inhibition of monoamine oxidase A, as well as by the lack of any anticholinergic action. Springer-Verlag, 1992 Cognition nationallicence Memory nationallicence Depression nationallicence Antidepressants nationallicence Psychometry nationallicence MAOI nationallicence Allain H. Experimental and Clinical Pharmacology Laboratory, Faculty of Medicine, Avenue du Pr. Leon Bernard, F-35043, Rennes, France aut Lieury A. Experimental Psychology Laboratory, University of Haute Bretagne, Avenue Gaston Berger, F-35043, Rennes, France aut Brunet-Bourgin F. Technopole Atalante, Biotrial, 20, rue Jean Pecker, F-35000, Rennes, France aut Mirabaud C. Roche Products, 52, Boulevard du Parc, F-92521, Neuilly/Seine Cedex, France aut Trebon P. Technopole Atalante, Biotrial, 20, rue Jean Pecker, F-35000, Rennes, France aut Le Coz F. Technopole Atalante, Biotrial, 20, rue Jean Pecker, F-35000, Rennes, France aut Gandon J. Technopole Atalante, Biotrial, 20, rue Jean Pecker, F-35000, Rennes, France aut Psychopharmacology Springer-Verlag 106(1992-02-01), S56-S61 0033-3158 106<S56 1992 106 213 https://doi.org/10.1007/BF02246237 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02246237 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Allain H. Experimental and Clinical Pharmacology Laboratory, Faculty of Medicine, Avenue du Pr. Leon Bernard, F-35043, Rennes, France aut NATIONALLICENCE 700 1- Lieury A. Experimental Psychology Laboratory, University of Haute Bretagne, Avenue Gaston Berger, F-35043, Rennes, France aut NATIONALLICENCE 700 1- Brunet-Bourgin F. Technopole Atalante, Biotrial, 20, rue Jean Pecker, F-35000, Rennes, France aut NATIONALLICENCE 700 1- Mirabaud C. Roche Products, 52, Boulevard du Parc, F-92521, Neuilly/Seine Cedex, France aut NATIONALLICENCE 700 1- Trebon P. Technopole Atalante, Biotrial, 20, rue Jean Pecker, F-35000, Rennes, France aut NATIONALLICENCE 700 1- Le Coz F. Technopole Atalante, Biotrial, 20, rue Jean Pecker, F-35000, Rennes, France aut NATIONALLICENCE 700 1- Gandon J. Technopole Atalante, Biotrial, 20, rue Jean Pecker, F-35000, Rennes, France aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106(1992-02-01), S56-S61 0033-3158 106<S56 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer