caa a22 4500 469121653 CHVBK 20180323133140.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF02246259 doi (NATIONALLICENCE)springer-10.1007/BF02246259 Chan-Palay V. Neurology Clinic, University Hospital, CH-8091, Zurich, Switzerland aut Depression and senile dementia of the Alzheimer type: a role for moclobemide [Elektronische Daten] [V. Chan-Palay] Depression is common in patients with senile dementia of the Alzheimer type (SDAT) and may precede the onset of the dementia; the underlying biological and neurotransmitter mechanisms may be common to both diseases, so far as norepinephrine lesions are concerned. The major routes of metabolism of amines in the brain utilize the monoamine oxidase (MAO) enzymes. Due to the consistent severity of norepinephrine lesions in the locus coeruleus of patients with pre-senile dementia or SDAT and the fact that MAO-A enzyme is the major metabolizing enzyme present in the locus coeruleus in man, the new specific, reversible MAO-A inhibitors may have a place in the treatment of depression associated with SDAT. Springer-Verlag, 1992 Norepinephrine nationallicence Mood nationallicence Monoamine oxidase nationallicence Presenile dementia nationallicence Immunocytochemistry nationallicence Psychopharmacology Springer-Verlag 106(1992-02-01), S137-S139 0033-3158 106<S137 1992 106 213 https://doi.org/10.1007/BF02246259 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02246259 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Chan-Palay V. Neurology Clinic, University Hospital, CH-8091, Zurich, Switzerland aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106(1992-02-01), S137-S139 0033-3158 106<S137 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer