caa a22 4500 469121688 CHVBK 20180323133140.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF02246228 doi (NATIONALLICENCE)springer-10.1007/BF02246228 Molecular neuroanatomy of monoamine oxidases in human brainstem [Elektronische Daten] [J. Richards, J. Saura, J. Ulrich, M. Da Prada] Specific, high-resolution techniques (quantitative enzyme radioautography and in situ hybridisation histochemistry) have revealed distribution, abundance and cellular localisation of the isoenzymes MAO-A and MAO-B and their mRNAs in human post-mortem brainstem. Whereas MAO-A protein and mRNA are expressed by noradrenergic neurons of the locus coeruleus, MAO-B protein and mRNA are expressed by serotoninergic neurons of the raphé nuclei. In the substantia nigra, MAO-B was more abundant than MAO-A; the former was localised in the reticular zone and the latter in the compact zone (where melanin-containing dopaminergic neurons are found). To date, it has not been possible to detect mRNA for either MAO-A or MAO-B in the substantia nigra or in glial cells of the brain regions investigated, suggesting either that the technique has limited sensitivity, or the possible existence of MAO-A and MAO-B subtypes. Springer-Verlag, 1992 Neuroanatomy nationallicence Monoamine oxidase nationallicence Richards J. Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd, Building 69, CH-4002, Basel, Switzerland aut Saura J. Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd, Building 69, CH-4002, Basel, Switzerland aut Ulrich J. Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd, Building 69, CH-4002, Basel, Switzerland aut Da Prada M. Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd, Building 69, CH-4002, Basel, Switzerland aut Psychopharmacology Springer-Verlag 106(1992-02-01), S21-S23 0033-3158 106<S21 1992 106 213 https://doi.org/10.1007/BF02246228 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02246228 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Richards J. Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd, Building 69, CH-4002, Basel, Switzerland aut NATIONALLICENCE 700 1- Saura J. Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd, Building 69, CH-4002, Basel, Switzerland aut NATIONALLICENCE 700 1- Ulrich J. Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd, Building 69, CH-4002, Basel, Switzerland aut NATIONALLICENCE 700 1- Da Prada M. Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd, Building 69, CH-4002, Basel, Switzerland aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106(1992-02-01), S21-S23 0033-3158 106<S21 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer