caa a22 4500 469121777 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF02246232 doi (NATIONALLICENCE)springer-10.1007/BF02246232 Pharmacokinetic and metabolic aspects of the moclobemide-food interaction [Elektronische Daten] [A. Cole, J. Baxter, B. Jackson, P. Hew-Wing, T. Güntert, D. Lalka] The effect of a protein-rich meal on the pharmacokinetics of moclobemide was studied after intravenous (75 mg) and oral (100 mg) administrations of this selective MAO-A inhibitor to eight healthy male volunteers. The meal chosen did not affect plasma concentration-time curves of the drug after oral administration apparently, because the influence of blood flow changes to the liver on hepatic first-pass metabolism (AUC↑) and on systemic clearance (AUC↓) balance each other out. Springer-Verlag, 1992 Moclobemide nationallicence Pharmacokinetics nationallicence Interaction nationallicence Food effect nationallicence Cole A. Department of Anaesthesia, Mount Sinai Hospital, Toronto, Canada aut Baxter J. Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, Amherst, NY, USA aut Jackson B. Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, 26506, Morgantown, WV, USA aut Hew-Wing P. Department of Anaesthesia, Mount Sinai Hospital, Toronto, Canada aut Güntert T. Department of Clinical Pharmacology, F. Hoffmann-La Roche Ltd, CH-4002, Basel, Switzerland aut Lalka D. Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, Amherst, NY, USA aut Psychopharmacology Springer-Verlag 106(1992-02-01), S37-S39 0033-3158 106<S37 1992 106 213 https://doi.org/10.1007/BF02246232 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02246232 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cole A. Department of Anaesthesia, Mount Sinai Hospital, Toronto, Canada aut NATIONALLICENCE 700 1- Baxter J. Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, Amherst, NY, USA aut NATIONALLICENCE 700 1- Jackson B. Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, 26506, Morgantown, WV, USA aut NATIONALLICENCE 700 1- Hew-Wing P. Department of Anaesthesia, Mount Sinai Hospital, Toronto, Canada aut NATIONALLICENCE 700 1- Güntert T. Department of Clinical Pharmacology, F. Hoffmann-La Roche Ltd, CH-4002, Basel, Switzerland aut NATIONALLICENCE 700 1- Lalka D. Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, Amherst, NY, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106(1992-02-01), S37-S39 0033-3158 106<S37 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer