caa a22 4500 469121793 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF02244811 doi (NATIONALLICENCE)springer-10.1007/BF02244811 Time course of D2-dopamine receptor occupancy examined by PET after single oral doses of haloperidol [Elektronische Daten] [Anna-Lena Nordström, Lars Farde, Christer Halldin] Central D2-dopamine receptor occupancy was followed by repeated PET experiments after administration of single oral doses of haloperidol to four healthy men. D2-dopamine receptor occupancy was high already 3 h after administration of 4 and 7.5 mg haloperidol and remained high for at least 27 h. Akathisia appeared when D2-dopamine receptor occupancy was maximal. After initiation of neuroleptic drug treatment several days or weeks may elapse before antipsychotic effect is evident. The results of this study do not indicate that any late onset of the antipsychotic effect is related to an insufficient D2-dopamine receptor occupancy during the first days of treatment. Springer-Verlag, 1992 D2-dopamine receptors nationallicence Human subjects nationallicence Positron emission tomography nationallicence Haloperidol nationallicence Brain nationallicence Nordström Anna-Lena Ulf Lundahl Research Unit, Department of Psychiatry and Psychology, The Karolinska Institute, S-104 01, Stockholm, Sweden aut Farde Lars Ulf Lundahl Research Unit, Department of Psychiatry and Psychology, The Karolinska Institute, S-104 01, Stockholm, Sweden aut Halldin Christer Ulf Lundahl Research Unit, Department of Psychiatry and Psychology, The Karolinska Institute, S-104 01, Stockholm, Sweden aut Psychopharmacology Springer-Verlag 106/4(1992-04-01), 433-438 0033-3158 106:4<433 1992 106 213 https://doi.org/10.1007/BF02244811 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244811 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nordström Anna-Lena Ulf Lundahl Research Unit, Department of Psychiatry and Psychology, The Karolinska Institute, S-104 01, Stockholm, Sweden aut NATIONALLICENCE 700 1- Farde Lars Ulf Lundahl Research Unit, Department of Psychiatry and Psychology, The Karolinska Institute, S-104 01, Stockholm, Sweden aut NATIONALLICENCE 700 1- Halldin Christer Ulf Lundahl Research Unit, Department of Psychiatry and Psychology, The Karolinska Institute, S-104 01, Stockholm, Sweden aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/4(1992-04-01), 433-438 0033-3158 106:4<433 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer