caa a22 4500 469121815 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF02244813 doi (NATIONALLICENCE)springer-10.1007/BF02244813 Dopaminergic control of locomotion, mouthing, snout contact, and grooming: opposing roles of D1 and D2 receptors [Elektronische Daten] [David Eilam, Hazel Talangbayan, Gitanjali Canaran, Henry Szechtman] The study compares the behavioral profiles induced in rats (N=118) by the D2-dopaminergic receptor agonist quinpirole (0.03 and 0.5 mg/kg), and the D1-agonist SKF38393 (1.25-40 mg/kg), and both agonists administered together. Locomotion and snout contact frequency were reduced by the low but increased by the high dose of quinpirole; SKF38393 also reduced these behaviors and attenuated the effect of the high quinpirole dose. Only the high dose of quinpirole increased the duration of snout contact bouts and the frequency of mouthing; SKF38393 had no effect but in combination with the high dose of quinpirole, it enhanced the performance of these behaviors greatly. The duration of mouthing bouts was not affected by either agonist but was greatly extended when SKF38393 was administered together with the high dose of quinpirole. Grooming was inhibited by both the low and the high dose of quinpirole, and stimulated by the injection of SKF38393 or its addition to the low dose of quinpirole. These findings suggest that snout contact is controlled by modulating the frequency of episodes whereas mouthing is controlled by modulating the duration of episodes. Moreover, although they do not disprove the prevailing notion of D1-D2 receptor synergism, the present data are consistent also with an oppositional model of D1-D2 receptor interaction in the regulation of locomotion, snout contact, mouthing, and grooming in intact animals. Springer-Verlag, 1992 Quinpirole nationallicence SKF38393 nationallicence Rats nationallicence Stereotyped behavior nationallicence D1/D2 interaction nationallicence Behavioral analysis nationallicence Eilam David Department of Biomedical Sciences, McMaster University, 1200 Main Street West, L8N 3Z5, Hamilton, Ontario, Canada aut Talangbayan Hazel Department of Biomedical Sciences, McMaster University, 1200 Main Street West, L8N 3Z5, Hamilton, Ontario, Canada aut Canaran Gitanjali Department of Biomedical Sciences, McMaster University, 1200 Main Street West, L8N 3Z5, Hamilton, Ontario, Canada aut Szechtman Henry Department of Biomedical Sciences, McMaster University, 1200 Main Street West, L8N 3Z5, Hamilton, Ontario, Canada aut Psychopharmacology Springer-Verlag 106/4(1992-04-01), 447-454 0033-3158 106:4<447 1992 106 213 https://doi.org/10.1007/BF02244813 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244813 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Eilam David Department of Biomedical Sciences, McMaster University, 1200 Main Street West, L8N 3Z5, Hamilton, Ontario, Canada aut NATIONALLICENCE 700 1- Talangbayan Hazel Department of Biomedical Sciences, McMaster University, 1200 Main Street West, L8N 3Z5, Hamilton, Ontario, Canada aut NATIONALLICENCE 700 1- Canaran Gitanjali Department of Biomedical Sciences, McMaster University, 1200 Main Street West, L8N 3Z5, Hamilton, Ontario, Canada aut NATIONALLICENCE 700 1- Szechtman Henry Department of Biomedical Sciences, McMaster University, 1200 Main Street West, L8N 3Z5, Hamilton, Ontario, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/4(1992-04-01), 447-454 0033-3158 106:4<447 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer