caa a22 4500 469121823 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF02244812 doi (NATIONALLICENCE)springer-10.1007/BF02244812 Effects of buprenorphine on self-administration of cocaine and a nondrug reinforcer in rats [Elektronische Daten] [Marilyn Carroll, Sylvie Lac] Nine groups of rats self-administered intravenously-delivered cocaine (0.1, 0.2, or 0.4 mg/kg) during 24-h sessions contingent upon lever-press responses under a fixed-ratio (FR) 4 schedule. Three other groups of rats responded on tongue-operated drinking devices for deliveries (0.01 ml) of a solution of glucose and saccharin (G+S). There were an additional three groups that initially self-administered cocaine (0.2 mg/kg), and later saline replaced cocaine and extinction behavior was allowed to stabilize. All 15 groups of rats were injected twice daily for 5 days with one of three doses of buprenorphine (0.1, 0.2 or 0.4 mg/kg). Buprenorphine decreased cocaine self-administration, but the effect of the highest dose was only slightly greater than that of the lowest dose tested. Cocaine infusions were reduced on the first day of treatment, but they increased over the next 4 days of buprenorphine injections. Buprenorphine decreased G+S intake during the last 2 or 3 days of injections. When buprenorphine treatment was terminated, G+S intake decreased even further. These lower rates of intake persisted for at least 5 days, and they returned to baseline by 2 weeks. Saline self-administration was decreased by buprenorphine in all saline extinction groups. Food intake was not altered by buprenorphine in the groups self-administering IV cocaine or saline; however, food intake was reduced in the G+S groups. Water intake increased during buprenorphine treatment in some of the cocaine groups but not in the G+S groups. Responding on the inactive lever was not altered by buprenorphine during cocaine or G+S self-administration, but it decreased in the saline extinction group. These data indicate that buprenorphine is effective in reducing cocaine reinforced behavior, but it also produced decrements in behavior rewarded by nondrug substances. Springer-Verlag, 1992 Buprenorphine nationallicence Cocaine self-administration nationallicence Drinking behavior nationallicence Intravenous rats nationallicence Carroll Marilyn Department of Psychiatry, University of Minnesota, Medical School, Box 392 UMHC, 55455, Minneapolis, MN, USA aut Lac Sylvie Department of Psychiatry, University of Minnesota, Medical School, Box 392 UMHC, 55455, Minneapolis, MN, USA aut Psychopharmacology Springer-Verlag 106/4(1992-04-01), 439-446 0033-3158 106:4<439 1992 106 213 https://doi.org/10.1007/BF02244812 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244812 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carroll Marilyn Department of Psychiatry, University of Minnesota, Medical School, Box 392 UMHC, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Lac Sylvie Department of Psychiatry, University of Minnesota, Medical School, Box 392 UMHC, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/4(1992-04-01), 439-446 0033-3158 106:4<439 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer