caa a22 4500 469121874 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF02244816 doi (NATIONALLICENCE)springer-10.1007/BF02244816 The kappa-opioid U-50,488H suppresses the initiation of nocturnal spontaneous drinking in normally hydrated rats [Elektronische Daten] [Aldo Badiani, Jane Stewart] The effect of a systemic (IP) treatment with 1.0, 3.0 and 9.0 mg/kg U-50,488H (U50), a highly selective kappa-agonist, on spontaneous, nocturnal ingestive behavior of the rat was studied using a microcomputer controlled data acquisition system. The latency to initiate drinking was increased and drinking behavior was suppressed in the first hour after injection in a dose-dependent manner. The consummatory indices of drinking were not affected. After this period of adipsia, a phase of polydipsia, that was probably due to the diuretic effect of U50, was evident. The prophagic effect of U50 was evident only at the dose of 3 mg/kg and was accompanied by an increased duration of feeding episodes but not by a reduced latency to feed. These results suggest that kappa-receptors play a pivotal role in modulating spontaneous drinking in the normally hydrated rat and that this control is mainly exerted on the motivational aspect of drinking. Springer-Verlag, 1992 U-50,488H nationallicence Kappa-agonists nationallicence Kappa-receptors nationallicence Opioids nationallicence Drinking nationallicence Feeding nationallicence Satiety nationallicence Motivation nationallicence Rat nationallicence Badiani Aldo Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, H3G 1M8, Montréal, Québec, Canada aut Stewart Jane Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, H3G 1M8, Montréal, Québec, Canada aut Psychopharmacology Springer-Verlag 106/4(1992-04-01), 463-473 0033-3158 106:4<463 1992 106 213 https://doi.org/10.1007/BF02244816 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244816 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Badiani Aldo Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, H3G 1M8, Montréal, Québec, Canada aut NATIONALLICENCE 700 1- Stewart Jane Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, H3G 1M8, Montréal, Québec, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/4(1992-04-01), 463-473 0033-3158 106:4<463 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer