caa a22 4500 469121890 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF02244815 doi (NATIONALLICENCE)springer-10.1007/BF02244815 Lack of effect of high-dose cocaine on monoamine uptake sites in rat brain measured by quantitative autoradiography [Elektronische Daten] [S. Benmansour, S. Tejani-Butt, M. Hauptmann, D. Brunswick] There have been a number of claims that high-dose administration of cocaine to rats leads to neurotoxic effects on dopamine neurons. In this study possible neurotoxic effects on monoamine neurons were examined by measuring the effects of cocaine (35 mg/kg daily for 10 days) on the binding of radioligands to uptake sites for dopamine, serotonin and norepinephrine using quatitative autoradiography. No effects of cocaine on any of the binding sites were observed and therefore, it is concluded that cocaine, unlike amphetamine derivatives which have similar pharmacologic properties, does not produce neurotoxic effects on monoamine neurons. Springer-Verlag, 1992 Neurotoxicity nationallicence Cocaine nationallicence Dopamine nationallicence Serotonin nationallicence Norepinephrine nationallicence Uptake sites nationallicence Benmansour S. Department of Psychiatry, University of Pennsylvania School of Medicine and Neuropsychopharmacology Unit, 19104, Philadelphia, PA, USA aut Tejani-Butt S. Department of Psychiatry, University of Pennsylvania School of Medicine and Neuropsychopharmacology Unit, 19104, Philadelphia, PA, USA aut Hauptmann M. Department of Psychiatry, University of Pennsylvania School of Medicine and Neuropsychopharmacology Unit, 19104, Philadelphia, PA, USA aut Brunswick D. Department of Psychiatry, University of Pennsylvania School of Medicine and Neuropsychopharmacology Unit, 19104, Philadelphia, PA, USA aut Psychopharmacology Springer-Verlag 106/4(1992-04-01), 459-462 0033-3158 106:4<459 1992 106 213 https://doi.org/10.1007/BF02244815 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244815 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Benmansour S. Department of Psychiatry, University of Pennsylvania School of Medicine and Neuropsychopharmacology Unit, 19104, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Tejani-Butt S. Department of Psychiatry, University of Pennsylvania School of Medicine and Neuropsychopharmacology Unit, 19104, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Hauptmann M. Department of Psychiatry, University of Pennsylvania School of Medicine and Neuropsychopharmacology Unit, 19104, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Brunswick D. Department of Psychiatry, University of Pennsylvania School of Medicine and Neuropsychopharmacology Unit, 19104, Philadelphia, PA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/4(1992-04-01), 459-462 0033-3158 106:4<459 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer