caa a22 4500 469121904 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF02244828 doi (NATIONALLICENCE)springer-10.1007/BF02244828 Behavioural tests of the dopamine depletion hypothesis of neuroleptic-induced response decrement [Elektronische Daten] [Paul Willner, Gavin Phillips, Richard Muscat, Peter Hood] This study was carried out to test the hypothesis that neuroleptic-induced within-session response decrements reflect a fatigue process, resulting from dopamine depletion, that is present before the session begins but is masked briefly by activational cues present at the start of the session. Response decrementing effects of pimozide were examined in rats lever pressing on random interval schedules of food reinforcement. An initial experiment was carried out to rule out a pharmacokinetic explanation of the response decrement. In a second experiment, the response decrement was not exacerbated by an immediately preceding period of intense forced motor activity (wheel running). Experiments 3 and 4 tested two further predictions: that the pimozide-induced response decrement should be overcome by removing the animal to its home cage and then replacing it in the apparatus (thereby reinstating the activational cues present at the start of the session); and that response impairments should be present from the outset if the animal is confined in the apparatus prior to the start of the session (thereby allowing activational cues to dissipate). Neither prediction was confirmed. Overall, the results provide no support for the dopamine depletion hypothesis. Springer-Verlag, 1992 Pimozide nationallicence Response decrement nationallicence Random-interval reinforcement schedules nationallicence Motor activation nationallicence Wheel-running nationallicence Rat nationallicence Willner Paul Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Phillips Gavin Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Muscat Richard Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Hood Peter Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Psychopharmacology Springer-Verlag 106/4(1992-04-01), 543-549 0033-3158 106:4<543 1992 106 213 https://doi.org/10.1007/BF02244828 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244828 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Willner Paul Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Phillips Gavin Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Muscat Richard Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Hood Peter Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/4(1992-04-01), 543-549 0033-3158 106:4<543 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer