caa a22 4500 469121912 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF02244825 doi (NATIONALLICENCE)springer-10.1007/BF02244825 Effects of cholinergic and non-cholinergic drugs on visual discrimination and delayed visual discrimination performance in rats [Elektronische Daten] [J. Andrews, M. Grützner, D. Stephens] The effects of several centrally active drugs were investigated using two visual discrimination tasks: a two-lever food-rewarded conditional brightness discrimination, and a similar conditional brightness discrimination where a delay was introduced between the disappearance of the stimulus and the opportunity to respond on the levers for food. The substances tested (amphetamine, scopolamine, methylscopolamine, physostigmine, diazepam andβ-carboline benzodiazepine receptor antagonist, ZK 93426), all produced differing profiles of action on the performance parameters recorded. In the simple conditional visual discrimination, amphetamine increased omissions without significant effects on accuracy or response latency. Physostigmine enhanced response latencies and failures to respond without significant effects on accuracy. ZK 93426 had no consistent effects on accuracy although at higher doses, some increase in response latency was seen in the delayed responding version of the visual discrimination task. Diazepam had negative effects on all parameters in both discrimination procedures. Scopolamine disrupted responding, but not accuracy in the simple discrimination, whereas accuracy was reduced in a dose, but not delay dependent manner in the delayed discrimination. A similar effect to that observed with scopolamine was observed following methylscopolamine in the delayed discrimination procedure. In the simple visual discrimination small increases in accuracy were recorded, accompanied by increased response latencies. Springer-Verlag, 1992 Visual discrimination nationallicence Delayed responding nationallicence Rats nationallicence Memory nationallicence Scopolamine nationallicence Methylscopolamine nationallicence Amphetamine nationallicence Physostigmine nationallicence Diazepam nationallicence ZK 93426 nationallicence Andrews J. Department of Neuropsychopharmacology, Research Laboratories of Schering AG, Postfach 65 03 11, W-1000, Berlin 65, Federal Republic of Germany aut Grützner M. Department of Neuropsychopharmacology, Research Laboratories of Schering AG, Postfach 65 03 11, W-1000, Berlin 65, Federal Republic of Germany aut Stephens D. Department of Neuropsychopharmacology, Research Laboratories of Schering AG, Postfach 65 03 11, W-1000, Berlin 65, Federal Republic of Germany aut Psychopharmacology Springer-Verlag 106/4(1992-04-01), 523-530 0033-3158 106:4<523 1992 106 213 https://doi.org/10.1007/BF02244825 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244825 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Andrews J. Department of Neuropsychopharmacology, Research Laboratories of Schering AG, Postfach 65 03 11, W-1000, Berlin 65, Federal Republic of Germany aut NATIONALLICENCE 700 1- Grützner M. Department of Neuropsychopharmacology, Research Laboratories of Schering AG, Postfach 65 03 11, W-1000, Berlin 65, Federal Republic of Germany aut NATIONALLICENCE 700 1- Stephens D. Department of Neuropsychopharmacology, Research Laboratories of Schering AG, Postfach 65 03 11, W-1000, Berlin 65, Federal Republic of Germany aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/4(1992-04-01), 523-530 0033-3158 106:4<523 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer