caa a22 4500 469121920 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF02244831 doi (NATIONALLICENCE)springer-10.1007/BF02244831 Social isolation does not alter brain regional benzodiazepine binding site numbers, affinity and coupling in the rat [Elektronische Daten] [Alun Morinan, Vivienne Parker, Delyth Rich, Peter Cariuk, Roger Horton] Male Sprague-Dawley rats were differentially housed for 21 days immediately after weaning. Isolated animals showed a selective suppression of exploration of the light side of a two compartment box; spending significantly less time in the light, and making fewer transitions between the light and dark compartments compared to socially reared controls. However, both basal and GABA-stimulated [3H] flunitrazepam binding was unaltered in the frontal cortex, hippocampus, amygdala and cerebellum following social isolation. These results are discussed in relation to other studies on central benzodiazepine receptor changes following a variety of experimental stressors. Springer-Verlag, 1992 Anxiety nationallicence Brain regions nationallicence [3H] flunitrazepam nationallicence GABA nationallicence Social isolation nationallicence Stress nationallicence Morinan Alun Department of Biological Sciences, North East Surrey College of Technology, Reigate Road, Ewell, KT17 3DS, Epsom, UK aut Parker Vivienne Department of Biological Sciences, North East Surrey College of Technology, Reigate Road, Ewell, KT17 3DS, Epsom, UK aut Rich Delyth Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, Cranmer Terrace, SW17 ORE, London, UK aut Cariuk Peter Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, Cranmer Terrace, SW17 ORE, London, UK aut Horton Roger Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, Cranmer Terrace, SW17 ORE, London, UK aut Psychopharmacology Springer-Verlag 106/4(1992-04-01), 565-569 0033-3158 106:4<565 1992 106 213 https://doi.org/10.1007/BF02244831 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244831 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morinan Alun Department of Biological Sciences, North East Surrey College of Technology, Reigate Road, Ewell, KT17 3DS, Epsom, UK aut NATIONALLICENCE 700 1- Parker Vivienne Department of Biological Sciences, North East Surrey College of Technology, Reigate Road, Ewell, KT17 3DS, Epsom, UK aut NATIONALLICENCE 700 1- Rich Delyth Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, Cranmer Terrace, SW17 ORE, London, UK aut NATIONALLICENCE 700 1- Cariuk Peter Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, Cranmer Terrace, SW17 ORE, London, UK aut NATIONALLICENCE 700 1- Horton Roger Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, Cranmer Terrace, SW17 ORE, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/4(1992-04-01), 565-569 0033-3158 106:4<565 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer