caa a22 4500 469121947 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF02244827 doi (NATIONALLICENCE)springer-10.1007/BF02244827 Effects of biperiden on sleep at baseline and after 72 h of REM sleep deprivation in the cat [Elektronische Daten] [Rafael Salin-Pascual, Anabel Jimenez-Anguiano, Daniel Granados-Fuentes, Rene Drucker-Colin] We examined the effects of the muscarinic M1 antagonist biperiden in cats. In the first experiment a dose-response analysis was performed with intraventricular injection (IV ventricle) of biperiden. In the second experiment after REM sleep deprivation cats were injected with either biperiden (0.1 mg/kg) or saline. Biperiden produced a reduction in REM sleep percentage and an increase in REM sleep latency with these high doses. The 0.1 mg/kg biperiden dose, which did not suppress REM sleep at baseline, did reduce the REM sleep rebound. The present study suggests a modulatory role of biperiden on REM sleep regulatory processes. The fact that an effect of biperiden is noted only at the high doses suggests that at these doses the drug is influencing non-M1 receptors. Changes in the sensitivity of these receptors as a result of REM sleep deprivation might explain why a dose of biperiden will reduce REM sleep rebound, while being ineffective in suppressing REM sleep at baseline. Springer-Verlag, 1992 Muscarinic receptors nationallicence REM sleep nationallicence Cholinergic nationallicence Biperiden nationallicence Cats nationallicence REM sleep deprivation nationallicence Salin-Pascual Rafael Sleep Disorders Center, Henry Ford Hospital, 2921 West Grand Boulevard, 48202-2689, Detroit, MI, USA aut Jimenez-Anguiano Anabel Departamento de Neurociencias, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico aut Granados-Fuentes Daniel Departamento de Neurociencias, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico aut Drucker-Colin Rene Departamento de Neurociencias, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico aut Psychopharmacology Springer-Verlag 106/4(1992-04-01), 540-542 0033-3158 106:4<540 1992 106 213 https://doi.org/10.1007/BF02244827 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244827 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Salin-Pascual Rafael Sleep Disorders Center, Henry Ford Hospital, 2921 West Grand Boulevard, 48202-2689, Detroit, MI, USA aut NATIONALLICENCE 700 1- Jimenez-Anguiano Anabel Departamento de Neurociencias, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico aut NATIONALLICENCE 700 1- Granados-Fuentes Daniel Departamento de Neurociencias, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico aut NATIONALLICENCE 700 1- Drucker-Colin Rene Departamento de Neurociencias, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/4(1992-04-01), 540-542 0033-3158 106:4<540 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer