caa a22 4500 469121971 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF02244817 doi (NATIONALLICENCE)springer-10.1007/BF02244817 Effects of early environmental experience on self-administration of amphetamine and barbital [Elektronische Daten] [Betty Zimmerberg, Marisa Brett] Rats were housed after weaning in isolation, with a same-sex sibling, or in a group in an enriched environment for 60 days. Then, subjects were trained to consume all of their fluids during a daily 2-h drinking session, habituated to drinking solutions of bothd-amphetamine sulfate and sodium barbital, and then given a choice between drinking water, the stimulant amphetamine and the depressant barbital. Drug choice was affected by both sex and previous housing condition. Males raised in social isolation preferred the stimulant, while females raised in isolation preferred the depressant. Both males and females raised in enriched environments expressed no drug preference, and had the lowest overall drug intake. These results suggest that individual differences in rates of initiation, choice of abusing agent, and maintenance of drug self-administration may be partially determined by pre-existing differences in central nervous system functioning due to early experiences. Differential early experience, particularly the stress of social isolation, can influence drug self-administration behavior, but the effect may be sex-dependent. Springer-Verlag, 1992 Self-administration nationallicence Amphetamine nationallicence Barbiturate nationallicence Social isolation nationallicence Enriched environment nationallicence Sex differences nationallicence Rats nationallicence Zimmerberg Betty Department of Psychology, Williams College, Bronfman Science Center, 01267, Williamstown, MA, USA aut Brett Marisa Department of Psychology, Williams College, Bronfman Science Center, 01267, Williamstown, MA, USA aut Psychopharmacology Springer-Verlag 106/4(1992-04-01), 474-478 0033-3158 106:4<474 1992 106 213 https://doi.org/10.1007/BF02244817 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244817 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zimmerberg Betty Department of Psychology, Williams College, Bronfman Science Center, 01267, Williamstown, MA, USA aut NATIONALLICENCE 700 1- Brett Marisa Department of Psychology, Williams College, Bronfman Science Center, 01267, Williamstown, MA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/4(1992-04-01), 474-478 0033-3158 106:4<474 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer