caa a22 4500 46912198X CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF02244818 doi (NATIONALLICENCE)springer-10.1007/BF02244818 Changes in dopamine D1, D2 and D3 receptor mRNA levels in rat brain following antipsychotic treatment [Elektronische Daten] [Paul Buckland, Michael O'Donovan, Peter McGuffin] The effects of administration of antipsychotic drugs (1-32 days, twice per day) on the rat brain mRNA levels of dopamine D1, D2 and D3 receptors has been assessed by a novel procedure utilising solution hybridisation with oligonucleotides. Saline and sulpiride (10 mg/kg/injection) had no effect on D1, D2 and D3 receptor mRNA levels. Haloperidol (1.5 mg/kg/injection) elicited increases in D1, D2 and D3 receptor mRNA levels of 100%, 100% and 300%, respectively, after 32 days and loxapine (2 mg/kg/injection) elicited increases of 450%, 150% and 550%, respectively. These results indicate that the up-regulation of dopamine receptors may be associated with the occurrence of tardive dyskinesia but not the clinical mode of action of antipsychotics. Springer-Verlag, 1992 Antipsychotics nationallicence Schizophrenia nationallicence Dopamine receptors nationallicence mRNA levels nationallicence Buckland Paul Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, CF4 4XN, Cardiff, UK aut O'Donovan Michael Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, CF4 4XN, Cardiff, UK aut McGuffin Peter Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, CF4 4XN, Cardiff, UK aut Psychopharmacology Springer-Verlag 106/4(1992-04-01), 479-483 0033-3158 106:4<479 1992 106 213 https://doi.org/10.1007/BF02244818 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244818 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Buckland Paul Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, CF4 4XN, Cardiff, UK aut NATIONALLICENCE 700 1- O'Donovan Michael Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, CF4 4XN, Cardiff, UK aut NATIONALLICENCE 700 1- McGuffin Peter Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, CF4 4XN, Cardiff, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/4(1992-04-01), 479-483 0033-3158 106:4<479 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer