caa a22 4500 469121998 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF02244833 doi (NATIONALLICENCE)springer-10.1007/BF02244833 Influence of intoxicated practice on the development of acute tolerance to the motor impairment effect of ethanol [Elektronische Daten] [A. Lê, H. Kalant] The influence of practice while under intoxication was tested on the development of acute tolerance to the motor impairment effect of ethanol. In experiment 1, the motor impairment effect induced by an IP injection of 1.8 g/kg ethanol was quantified after various intervals in separate groups of animals. Lower impairment scores were observed in rats tested at 30 and 45 min after ethanol administration than in those tested at 15 min. In group that was tested repeatedly after ethanol administration, intoxication decreased more rapidly and to a greater extent. The same phenomenon was observed in experiment 2 when a higher dose of ethanol (2.2 g/kg) and later testing (60-180 min after ethanol administration) were employed. To maintain constant blood ethanol levels, those testedat later times received a supplementary dose of ethanol. Impairment scores were lower in rats tested at later times than in those tested earlier. Again, the impairment scores for the practice group decreased more rapidly and to a greater extent. Blood ethanol levels among various groups were essentially the same. Acute tolerance to ethanol can develop without opportunity for practice while under intoxication. Intoxicated practice, however, can facilitate acute tolerance development. Springer-Verlag, 1992 Ethanol nationallicence Acute tolerance nationallicence Motor impairment nationallicence Intoxicated practice nationallicence Lê A. Department of Primary Mechanisms Research and Development, Addiction Research Foundation of Ontario, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut Kalant H. Department of Primary Mechanisms Research and Development, Addiction Research Foundation of Ontario, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut Psychopharmacology Springer-Verlag 106/4(1992-04-01), 572-576 0033-3158 106:4<572 1992 106 213 https://doi.org/10.1007/BF02244833 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244833 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lê A. Department of Primary Mechanisms Research and Development, Addiction Research Foundation of Ontario, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Kalant H. Department of Primary Mechanisms Research and Development, Addiction Research Foundation of Ontario, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/4(1992-04-01), 572-576 0033-3158 106:4<572 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer