caa a22 4500 469122013 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF02244830 doi (NATIONALLICENCE)springer-10.1007/BF02244830 Effects of bromazepam on single-trial event-related potentials in a visual vigilance task [Elektronische Daten] [T. van Leeuwen, M. Verbaten, H. Koelega, J. Kenemans, J. Slangen] Thirty females performed a visual vigilance task under the influence of bromazepam (6 and 12 mg) in a placebo-controlled, double blind, experiment. Measures employed were percentage of hits, percentage of false alarms, response latency (RT), A′ (sensitivity), B″ (cautiousness), and RI (responsivity), as well as signal-and non-signal event-related potentials (ERPs). Bromazepam did not aggravate the normally occurring decrement in performance in vigilance tasks, but had an effect on overall level of performance: accuracy was reduced under the influence of the drug, but speed improved. A Drug×Period interaction for cautiousness (B″) indicated increasingly less cautiousness with bromazepam, which probably contributed to faster motor responses (and more errors) than in the placebo group. The ERP data suggest that the effects of bromazepam are already manifest in the early stages of information processing (attention-detection) as mirrored by a drug effect on N1 amplitude. Deterioration at this early stage may affect later processing stages (P2-N2 amplitudes). As a result, subjects under the influence of the drug probably accumulate less signal evidence for their final evaluation. Springer-Verlag, 1992 Benzodiazepines nationallicence Vigilance performance nationallicence Event-related potentials nationallicence van Leeuwen T. Faculty of Pharmacy, Psychopharmacology Section, University of Utrecht, Sorbonnelaan 16, NL-3584 CA, Utrecht, The Netherlands aut Verbaten M. Faculty of Pharmacy, Psychopharmacology Section, University of Utrecht, Sorbonnelaan 16, NL-3584 CA, Utrecht, The Netherlands aut Koelega H. Psychological Laboratory, University of Utrecht, Sorbonnelaan 16, NL-3584 CA, Utrecht, The Netherlands aut Kenemans J. Faculty of Pharmacy, Psychopharmacology Section, University of Utrecht, Sorbonnelaan 16, NL-3584 CA, Utrecht, The Netherlands aut Slangen J. Faculty of Pharmacy, Psychopharmacology Section, University of Utrecht, Sorbonnelaan 16, NL-3584 CA, Utrecht, The Netherlands aut Psychopharmacology Springer-Verlag 106/4(1992-04-01), 555-564 0033-3158 106:4<555 1992 106 213 https://doi.org/10.1007/BF02244830 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244830 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Leeuwen T. Faculty of Pharmacy, Psychopharmacology Section, University of Utrecht, Sorbonnelaan 16, NL-3584 CA, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Verbaten M. Faculty of Pharmacy, Psychopharmacology Section, University of Utrecht, Sorbonnelaan 16, NL-3584 CA, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Koelega H. Psychological Laboratory, University of Utrecht, Sorbonnelaan 16, NL-3584 CA, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Kenemans J. Faculty of Pharmacy, Psychopharmacology Section, University of Utrecht, Sorbonnelaan 16, NL-3584 CA, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Slangen J. Faculty of Pharmacy, Psychopharmacology Section, University of Utrecht, Sorbonnelaan 16, NL-3584 CA, Utrecht, The Netherlands aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/4(1992-04-01), 555-564 0033-3158 106:4<555 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer