caa a22 4500 469122021 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF02244826 doi (NATIONALLICENCE)springer-10.1007/BF02244826 Evidence for differential effects of 8-OH-DPAT on male and female rats in the Anxiety/Defense Test Battery [Elektronische Daten] [D. Blanchard, Jon Shepherd, R. Rodgers, Robert Blanchard] The Proxemics/Activity test and the Eat/Drink test, two components of the Anxiety/Defense Test Battery, were developed to measure defensive reactions to situations associated with a natural predator (cat). In the present studies the behavioral effects of 8-OH-DPAT treatment (0.01-1.0 mg/kg, SC) were entirely consistent with anxiety/fear reduction. These effects included an increase in time spent near the cat compartment, and a complimentary decrease in time spent farthest from this compartment, together with an increase in transits and locomote behavior. 8-OH-DPAT (1.0 mg/kg) also increased eat frequencies and durations (highly preferred food) both during and following cat presentation, without influencing drinking. This finding is discussed with reference to previous findings with 8-OH-DPAT in studies assessing both food intake and anxiolysis. Interestingly, 8-OH-DPAT was more potent in a majority of its effects in female subjects, a finding consistent with recent neurochemical data. These findings provide important behavioral evidence for a sexual differentiation in 5-HT function, and support the case for greater emphasis on female subjects in animal models of anxiety. Springer-Verlag, 1992 8-OH-DPAT nationallicence Serotonin nationallicence 5-HT1A nationallicence Anxiety nationallicence Defense nationallicence Fear nationallicence Risk assessment nationallicence Animal model nationallicence Sex differences nationallicence Grooming nationallicence Blanchard D. Bekesy Laboratory of Neurobiology, John A. Burns School of Medicine, University of Hawaii, 1993 East-West Road, 96822, Honolulu, HI, USA aut Shepherd Jon Bekesy Laboratory of Neurobiology, John A. Burns School of Medicine, University of Hawaii, 1993 East-West Road, 96822, Honolulu, HI, USA aut Rodgers R. Department of Psychology, University of Leeds, LS2 9JT, Leeds, UK aut Blanchard Robert Bekesy Laboratory of Neurobiology, John A. Burns School of Medicine, University of Hawaii, 1993 East-West Road, 96822, Honolulu, HI, USA aut Psychopharmacology Springer-Verlag 106/4(1992-04-01), 531-539 0033-3158 106:4<531 1992 106 213 https://doi.org/10.1007/BF02244826 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244826 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Blanchard D. Bekesy Laboratory of Neurobiology, John A. Burns School of Medicine, University of Hawaii, 1993 East-West Road, 96822, Honolulu, HI, USA aut NATIONALLICENCE 700 1- Shepherd Jon Bekesy Laboratory of Neurobiology, John A. Burns School of Medicine, University of Hawaii, 1993 East-West Road, 96822, Honolulu, HI, USA aut NATIONALLICENCE 700 1- Rodgers R. Department of Psychology, University of Leeds, LS2 9JT, Leeds, UK aut NATIONALLICENCE 700 1- Blanchard Robert Bekesy Laboratory of Neurobiology, John A. Burns School of Medicine, University of Hawaii, 1993 East-West Road, 96822, Honolulu, HI, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/4(1992-04-01), 531-539 0033-3158 106:4<531 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer