caa a22 4500 46912203X CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF02244824 doi (NATIONALLICENCE)springer-10.1007/BF02244824 Pharmacokinetics of haloperidol and reduced haloperidol in chinese schizophrenic patients after intravenous and oral administration of haloperidol [Elektronische Daten] [Wen-Ho Chang, Y. Francis Lam, Michael Jann, Hong Chen] The pharmacokinetics of haloperidol were studied in eight Chinese schizophrenic patients after intravenous administration and in six of the patients who also received oral haloperidol. After intravenous dosing, haloperidol disposition was best characterized by a three compartment model. The mean elimination half-life of 54.8 h determined by model dependent analysis was similar to the mean elimination half-life of 59.9 h determined by model independent analysis. The mean plasma clearance was 21.7 l/h and the mean volume of distribution during the distribution phase was 1754.3 l. After oral dosing, bioavailability of haloperidol was 35±8%, suggesting extensive first pass metabolism. Determination of reduced haloperidol concentration confirmed a previous finding of significant variability in haloperidol reductive capacity in individual patients. Comparison of area under the plasma concentration-time curve of reduced haloperidol after intravenous and oral administration of haloperidol suggests that reduction of haloperidol may only account for a small portion of first pass metabolism of haloperidol. However, conversion of reduced haloperidol back to haloperidol necessitates the monitoring of both haloperidol and reduced haloperidol concentrations in clinical practice. Springer-Verlag, 1992 Haloperidol nationallicence Reduced haloperidol nationallicence Pharmacokinetics nationallicence Chinese schizophrenics nationallicence Chang Wen-Ho Laboratory of Biological Psychiatry, Taipei City Psychiatric Center, 309 Sung-Te Road, 10510, Taipei, Taiwan, Republic of China aut Francis Lam Y. Department of Pharmacology, University of Texas Health Science Center at San Antonio, 78284-7765, San Antonio, TX, USA aut Jann Michael Departments of Pharmacy Practice and Pharmaceutical Science, Mercer University, Southern School of Pharmacy, 3001 Mercer University Drive, 30341, Atlanta, GA, USA aut Chen Hong Laboratory of Biological Psychiatry, Taipei City Psychiatric Center, 309 Sung-Te Road, 10510, Taipei, Taiwan, Republic of China aut Psychopharmacology Springer-Verlag 106/4(1992-04-01), 517-522 0033-3158 106:4<517 1992 106 213 https://doi.org/10.1007/BF02244824 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244824 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chang Wen-Ho Laboratory of Biological Psychiatry, Taipei City Psychiatric Center, 309 Sung-Te Road, 10510, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Francis Lam Y. Department of Pharmacology, University of Texas Health Science Center at San Antonio, 78284-7765, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Jann Michael Departments of Pharmacy Practice and Pharmaceutical Science, Mercer University, Southern School of Pharmacy, 3001 Mercer University Drive, 30341, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Chen Hong Laboratory of Biological Psychiatry, Taipei City Psychiatric Center, 309 Sung-Te Road, 10510, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/4(1992-04-01), 517-522 0033-3158 106:4<517 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer