caa a22 4500 469122048 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02801968 doi (NATIONALLICENCE)springer-10.1007/BF02801968 Differences in the hypothermic response to ethanol in rats selectively bred for oral ethanol preference and nonpreference [Elektronische Daten] [R. Stewart, D. Kurtz, M. Zweifel, T. Li, J. Froehlich] The duration of retention of tolerance to ethanol was tested in the alcohol-preferring (P) and alcohol-nonpreferring (NP) rats lines, using ethanol-induced hypothermia as a measure of tolerance. Rats received two injections of ethanol (3.5 g/kg) body wt, IP) and the time between the injections was 1, 2, or 3 days. When one day separated the two injections, tolerance to the hypothermic effect of a second "test” injection was found in both lines. When 2 or 3 days separated the two injections, the P line showed a loss of tolerance and the NP line showed sensitization to ethanol. Sensitization in the NP line grew stronger when the interval between injections was increased from 2 to 3 days. The duration of retention of tolerance to ethanol-induced hypothermia in the P line was shorter than has previously been reported for motor impairment in this line. It appears that the duration of tolerance retention in the P line depends on the test used to measure tolerance. Sensitization to ethanol in the NP line may be associated with low oral ethanol intake. Springer-Verlag, 1992 Alcohol-preferring rats nationallicence Alcohol-nonpreferring rat nationallicence Tolerance nationallicence Hypothermia nationallicence Ethanol-induced hypothermia nationallicence Rapid tolerance nationallicence Stewart R. Department of Medicine, Indiana University School of Medicine, Emerson Hall 421, 545 Barnhill Drive, 46202-5124, Indianapolis, IN, USA aut Kurtz D. Department of Medicine, Indiana University School of Medicine, Emerson Hall 421, 545 Barnhill Drive, 46202-5124, Indianapolis, IN, USA aut Zweifel M. Department of Medicine, Indiana University School of Medicine, Emerson Hall 421, 545 Barnhill Drive, 46202-5124, Indianapolis, IN, USA aut Li T. Department of Medicine, Indiana University School of Medicine, Emerson Hall 421, 545 Barnhill Drive, 46202-5124, Indianapolis, IN, USA aut Froehlich J. Department of Medicine, Indiana University School of Medicine, Emerson Hall 421, 545 Barnhill Drive, 46202-5124, Indianapolis, IN, USA aut Psychopharmacology Springer-Verlag 106/2(1992-06-01), 169-174 0033-3158 106:2<169 1992 106 213 https://doi.org/10.1007/BF02801968 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02801968 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stewart R. Department of Medicine, Indiana University School of Medicine, Emerson Hall 421, 545 Barnhill Drive, 46202-5124, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Kurtz D. Department of Medicine, Indiana University School of Medicine, Emerson Hall 421, 545 Barnhill Drive, 46202-5124, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Zweifel M. Department of Medicine, Indiana University School of Medicine, Emerson Hall 421, 545 Barnhill Drive, 46202-5124, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Li T. Department of Medicine, Indiana University School of Medicine, Emerson Hall 421, 545 Barnhill Drive, 46202-5124, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Froehlich J. Department of Medicine, Indiana University School of Medicine, Emerson Hall 421, 545 Barnhill Drive, 46202-5124, Indianapolis, IN, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/2(1992-06-01), 169-174 0033-3158 106:2<169 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer