caa a22 4500 469122072 CHVBK 20180323133141.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02801979 doi (NATIONALLICENCE)springer-10.1007/BF02801979 Cocaine facilitation of prefrontal cortex self-stimulation: a microstructural and pharmacological analysis [Elektronische Daten] [Iain McGregor, Dale Atrens, David Jackson] A novel self-stimulation methodology involving a fixed-interval (FI-5 s) schedule of reinforcement, microanalysis and threshold evaluation was used to investigate the effects of cocaine on rats lever pressing for electrical stimulation of the prefrontal cortex. Cocaine (15 mg/kg) increased medial prefrontal cortex (MPC) self-stimulation rates under FI-5 by a mean of 269% and reduced current thresholds for self-stimulation. A similar facilitation was evident with self-stimulation of the sulcal prefrontal cortex. Microanalysis showed that cocaine decreased inter-response times and post-reinforcement pauses, increased responding in the second and third quartiles of the inter-reinforcement interval (IRI) and decreased responding in the fourth IRI quartile. Schedule control of responding was still evident following cocaine despite the profound facilitation of response rates. Increased response rates were seen up to 48 h following a single dose of cocaine, suggesting sensitization of the PFC reinforcement substrate. The acute effects of cocaine on MPC self-stimulation were completely reversed by the dopamine (DA) D1 antagonist SCH 23390 0.02 mg/kg) and the D2 antagonist raclopride (0.3 mg/kg) but not by naloxone (0.5 mg/kg). These results are consistent with previous studies demonstrating the PFC as part of the neural substrate mediating cocaine reward. Further, these results implicate DA receptors in the reinforcing properties of both cocaine and MPC self-stimulation. Springer-Verlag, 1992 Medial prefrontal cortex nationallicence Sulcal prefrontal cortex nationallicence Self-stimulation nationallicence Reward nationallicence Cocaine nationallicence Microstructure nationallicence SCH 23390 nationallicence Raclopride nationallicence Naloxone nationallicence Fixedinterval nationallicence McGregor Iain Department of Psychology, University of Sydney, 2006, NSW, Australia aut Atrens Dale Department of Psychology, University of Sydney, 2006, NSW, Australia aut Jackson David Astra Research Centre AB, S-15185, Sodertälje, Sweden aut Psychopharmacology Springer-Verlag 106/2(1992-06-01), 239-247 0033-3158 106:2<239 1992 106 213 https://doi.org/10.1007/BF02801979 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02801979 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McGregor Iain Department of Psychology, University of Sydney, 2006, NSW, Australia aut NATIONALLICENCE 700 1- Atrens Dale Department of Psychology, University of Sydney, 2006, NSW, Australia aut NATIONALLICENCE 700 1- Jackson David Astra Research Centre AB, S-15185, Sodertälje, Sweden aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/2(1992-06-01), 239-247 0033-3158 106:2<239 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer