caa a22 4500 469122110 CHVBK 20180323133142.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02801973 doi (NATIONALLICENCE)springer-10.1007/BF02801973 Benzodiazepine-induced decreases in extracellular concentrations of dopamine in the nucleus accumbens after acute and repeated administration [Elektronische Daten] [J. Finlay, G. Damsma, H. Fibiger] In vivo microdialysis was used to assess the effects of acute and repeated injections of the benzodiazepine midazolam on extracellular dopamine (DA) concentrations in the nucleus accumbens. Acute administration of midazolam (5 mg/kg, SC) elicited a 22% decrease in extracellular DA in the nucleus accumbens but failed to affect DA concentrations in the striatum. Similarly, six spaced intravenous infusions of midazolam, at a dose that has previously been found to support self-administration (0.05 mg per infusion), produced a 50% decrease in extracellular DA in the nucleus accumbens. In order to assess the effects of subchronic midazolam injections, two groups of rats were given injections of saline or midazolam (5 mg/kg, SC) for 14 days (two injections per day). A subsequent challenge injection of midazolam (5 mg/kg) decreased extracellular DA in the nucleus accumbens by 25% in both groups, indicating that neither tolerance nor sensitization occurred during the repeated drug administration. These experiments indicate (1) that midazolam differentially affects meso-accumbens and nigrostriatal DA neurons, and (2) that the midazolam-induced decrease in extracellular DA in the nucleus accumbens is not affected by repeated drug administration. The data further suggest that the rewarding effects of midazolam are not associated with increased release of DA in the nucleus accumbens. Springer-Verlag, 1992 Microdialysis nationallicence Nucleus accumbens nationallicence Striatum nationallicence Dopamine nationallicence Benzodiazepines nationallicence Finlay J. Division of Neurological Sciences, Department of Psychiatry, University of British Columbia, V6T 1W5, Vancouver, BC, Canada aut Damsma G. Division of Neurological Sciences, Department of Psychiatry, University of British Columbia, V6T 1W5, Vancouver, BC, Canada aut Fibiger H. Division of Neurological Sciences, Department of Psychiatry, University of British Columbia, V6T 1W5, Vancouver, BC, Canada aut Psychopharmacology Springer-Verlag 106/2(1992-06-01), 202-208 0033-3158 106:2<202 1992 106 213 https://doi.org/10.1007/BF02801973 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02801973 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Finlay J. Division of Neurological Sciences, Department of Psychiatry, University of British Columbia, V6T 1W5, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- Damsma G. Division of Neurological Sciences, Department of Psychiatry, University of British Columbia, V6T 1W5, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- Fibiger H. Division of Neurological Sciences, Department of Psychiatry, University of British Columbia, V6T 1W5, Vancouver, BC, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/2(1992-06-01), 202-208 0033-3158 106:2<202 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer