caa a22 4500 469122137 CHVBK 20180323133142.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02801977 doi (NATIONALLICENCE)springer-10.1007/BF02801977 Serotonin2 receptor agonists and serotonergic anorectic drugs affect rats' performance differently in a five-choice serial reaction time task [Elektronische Daten] [Mirjana Carli, Rosario Samanin] A five-choice serial reaction time task was used to study the effects of serotonin (5-HT) receptor agonists and antagonists on accuracy of performance and food-motivated behaviour. Lysergic acid diethylamide (LSD), 0.1 mg/kg IP and quipazine, 2.5 mg/kg IP significantly reduced the percentage of correct responses and increased the percentage of omissions with no effect on other measures such as latency to collect the reinforcement or to respond correctly. The effects of LSD and quipazine were reversed by 1-2 mg/kg ritanserin, a potent 5-HT2 and 5-HT1C receptor antagonist. Metachlorophenylpiperazine (mCPP) 2.5 mg/kg IP, an agonist at 5-HT1B and 5-HT1C receptors, andd-fenfluramine (DF) 1.25 mg/kg IP, a releaser of 5-HT from nerve terminals and inhibitor of 5-HT uptake, increased the percentage of omissions and the latency to respond correctly or to collect the reinforcement with no effects on the correct responses. Effects similar to those of mCPP and DF were obtained by 60 min access to food before testing. Haloperidol, 0.1 mg/kg IP, did not affect the percentage of correct responses or the latency to collect the reinforcement, but significantly increased the proportion of errors of omission and the latency to respond correctly. The results show that 5-HT2 receptor agonists cause attentional disturbances at doses that have no marked effect on motivation for food or speed. An increase in the latency to collect the reinforcement was found only with prefeeding and drugs supposed to cause satiety such as mCPP and DF. An increase in latency to respond correctly and in the percentage of omissions seemed related to haloperidol-induced motor retardation and reduced level of arousal. The five-choice serial reaction time task seems useful for separating effects on attentional processes from those on food-motivated behaviour or motor activity. Springer-Verlag, 1992 Discrimination nationallicence Attention nationallicence Satiety nationallicence Arousal nationallicence Lysergic acid diethylamide nationallicence Quipazine nationallicence m-Chlorophenylpiperazine nationallicence d -Fenfluramine nationallicence 5-HT2 receptors nationallicence Carli Mirjana Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milano, Italy aut Samanin Rosario Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milano, Italy aut Psychopharmacology Springer-Verlag 106/2(1992-06-01), 228-234 0033-3158 106:2<228 1992 106 213 https://doi.org/10.1007/BF02801977 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02801977 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carli Mirjana Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milano, Italy aut NATIONALLICENCE 700 1- Samanin Rosario Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milano, Italy aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/2(1992-06-01), 228-234 0033-3158 106:2<228 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer