caa a22 4500 469122145 CHVBK 20180323133142.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02801970 doi (NATIONALLICENCE)springer-10.1007/BF02801970 Blockade of conditioned taste aversion by scopolamine and N-methyl scopolamine: associative conditioning, not amnesia [Elektronische Daten] [J. Evenden, L. Lavis, S. Iversen] The anticholinergic, scopolamine, consistently disrupts one-trial passive avoidance conditioning but the effects of such drugs on one-trial conditioned taste aversion (CTA) are variable and contradictory. In the present study, treatment of rats with scopolamine impaired the suppression of sucrose intake by post-ingestion administration of lithium chloride (LiCl) in a two-bottle choice test. A similar effect was obtained by using N-methyl scopolamine which penetrates the brain only to a limited degree on acute administration. The blockade of CTA could be prevented in three ways: (i) by exposing the rats to sucrose only on the training day, (ii) by pre-exposing the rats to both sucrose and scopolamine, and (iii) by using a less palatable sucrose/ascorbate mixture. The results demonstrate that the effect of scopolamine on taste aversion is not mediated by the central nervous system, and can be modified by altering the novelty and relative salience of the taste conditioned stimulus. These experiments suggest that conditioned associations between taste and LiCl, and scopolamine and LiCl may underlie the blockade of CTA by scopolamine. Springer-Verlag, 1992 Scopolamine nationallicence Conditioned taste aversion nationallicence Amnesia nationallicence Associative conditioning nationallicence Rat nationallicence Evenden J. Merck, Sharpe and Dohme Neuroscience Research Centre, Terlings Park, Harlow, Essex, UK aut Lavis L. Merck, Sharpe and Dohme Neuroscience Research Centre, Terlings Park, Harlow, Essex, UK aut Iversen S. Merck, Sharpe and Dohme Neuroscience Research Centre, Terlings Park, Harlow, Essex, UK aut Psychopharmacology Springer-Verlag 106/2(1992-06-01), 179-188 0033-3158 106:2<179 1992 106 213 https://doi.org/10.1007/BF02801970 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02801970 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Evenden J. Merck, Sharpe and Dohme Neuroscience Research Centre, Terlings Park, Harlow, Essex, UK aut NATIONALLICENCE 700 1- Lavis L. Merck, Sharpe and Dohme Neuroscience Research Centre, Terlings Park, Harlow, Essex, UK aut NATIONALLICENCE 700 1- Iversen S. Merck, Sharpe and Dohme Neuroscience Research Centre, Terlings Park, Harlow, Essex, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/2(1992-06-01), 179-188 0033-3158 106:2<179 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer