caa a22 4500 469122153 CHVBK 20180323133142.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02801976 doi (NATIONALLICENCE)springer-10.1007/BF02801976 A comparison of the effects of d- and l-fenfluramine and d-amphetamine on energy and macronutrient intake in human subjects [Elektronische Daten] [Elizabeth Goodall, Sean Feeney, Joan McGuirk, Trevor Silverstone] The anorectic activity of thed andl isomers ofd-fenfluramine (d-FF) (l-FF) were compared withd-amphetamine (d-amp) when given separately and together in 12 healthy male volunteers. The study was double blind and placebo controlled. Food intake was measured using an automated food dispenser. Anorectic activity was examined using a) total energy intake b) nutrient selection c) selection of foods categorised by nonsweet/sweet taste. Total energy intake was significantly reduced byd-FF (17%)d-amp (26%)d-FF+d-amp (36%) andl-FF+d-amp (31%).d-Amp and both combinations significantly reduced energy intake from all macronutrients in the total food.d-FF reduced carbohydrate but not fat or protein intake derived from all foods. When nonsweet and sweet tasting foods were examined separately,l-FF also significantly reduced energy (by 19%), fat and carbohydrate intake from nonsweet food. Neitherd-FF norl-FF reduced protein from nonsweet food. No anorectic drug given alone reduced sweet food intake, onlyd-amp given withd-FF had this effect. In contrast to nonsweet food,d-FF did not reduce carbohydrate from sweet foods. The results are in agreement with previous work thatd-FF spares protein consumption but suggest thatd-FF does not selectively reduce carbohydrate intake per se. Springer-Verlag, 1992 d -Fenfluramine nationallicence l -Fenfluramine nationallicence d -Amphetamine nationallicence Food intake nationallicence Anorexia nationallicence Nutrient selection nationallicence Taste nationallicence Goodall Elizabeth Academic Unit of Human Psychopharmacology, Medical College of St. Bartholomew's Hospital, London, UK aut Feeney Sean Academic Unit of Human Psychopharmacology, Medical College of St. Bartholomew's Hospital, London, UK aut McGuirk Joan Academic Unit of Human Psychopharmacology, Medical College of St. Bartholomew's Hospital, London, UK aut Silverstone Trevor Academic Unit of Human Psychopharmacology, Medical College of St. Bartholomew's Hospital, London, UK aut Psychopharmacology Springer-Verlag 106/2(1992-06-01), 221-227 0033-3158 106:2<221 1992 106 213 https://doi.org/10.1007/BF02801976 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02801976 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goodall Elizabeth Academic Unit of Human Psychopharmacology, Medical College of St. Bartholomew's Hospital, London, UK aut NATIONALLICENCE 700 1- Feeney Sean Academic Unit of Human Psychopharmacology, Medical College of St. Bartholomew's Hospital, London, UK aut NATIONALLICENCE 700 1- McGuirk Joan Academic Unit of Human Psychopharmacology, Medical College of St. Bartholomew's Hospital, London, UK aut NATIONALLICENCE 700 1- Silverstone Trevor Academic Unit of Human Psychopharmacology, Medical College of St. Bartholomew's Hospital, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/2(1992-06-01), 221-227 0033-3158 106:2<221 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer