caa a22 4500 469122161 CHVBK 20180323133142.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02801978 doi (NATIONALLICENCE)springer-10.1007/BF02801978 Spinal cord alpha-2 noradrenergic receptors mediate conditioned analgesia [Elektronische Daten] [Joseph Rochford, Benoit Dubé, Patricia Dawes] The present experiment investigated the effects of direct spinal administration of the monoaminergic receptor blockers yohimbine, phentolamine and methysergide on the expression of conditioned analgesia. Animals in the Paired group received classical conditioning trials in which one context was paired with footshock administration (1 mA shock for 15 s). Animals in the Unpaired control group were administered shock in a second, different, context. On the test day animals within each condition were administered saline (20 μl), yohimbine (30 μg), phentolamine (30 μg), or methysergide (30 μg) prior to receiving a hot plate test (50° C) in the context previously used to shock the Paired group. These ligands were administered into the spinal fluid through a chronic, indwelling spinal catheter. Animals in the Paired group which received saline displayed longer paw lick latencies than saline-treated animals in the Unpaired group. Yohimbine, but not phentolamine or methysergide, attenuated this conditioned analgesia. These results suggest that spinal cord noradrenergic substrates mediate conditioned analgesia, and that this mediation occurs specifically through the alpha-2 noradrenergic receptor. Springer-Verlag, 1992 Conditioned analgesia nationallicence Noradrenalin nationallicence Serotonin nationallicence Alpha receptor subtypes nationallicence Spinal cord nationallicence Rochford Joseph Department of Psychology, Concordia University, 7141 Sherbrooke Street West, H4B 1R6, Montreal, Quebec, Canada aut Dubé Benoit Department of Psychology, Concordia University, 7141 Sherbrooke Street West, H4B 1R6, Montreal, Quebec, Canada aut Dawes Patricia Department of Psychology, Concordia University, 7141 Sherbrooke Street West, H4B 1R6, Montreal, Quebec, Canada aut Psychopharmacology Springer-Verlag 106/2(1992-06-01), 235-238 0033-3158 106:2<235 1992 106 213 https://doi.org/10.1007/BF02801978 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02801978 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rochford Joseph Department of Psychology, Concordia University, 7141 Sherbrooke Street West, H4B 1R6, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Dubé Benoit Department of Psychology, Concordia University, 7141 Sherbrooke Street West, H4B 1R6, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Dawes Patricia Department of Psychology, Concordia University, 7141 Sherbrooke Street West, H4B 1R6, Montreal, Quebec, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/2(1992-06-01), 235-238 0033-3158 106:2<235 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer