caa a22 4500 46912217X CHVBK 20180323133142.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02801971 doi (NATIONALLICENCE)springer-10.1007/BF02801971 Discriminative stimulus effects of cyclorphan: selective antagonism with naltrexone [Elektronische Daten] [Albert Bertalmio, James Woods] The opioid antagonist, naltrexone, was used to identify some of the receptor mechanisms responsible for the discriminative stimulus effects of cyclorphan in the pigeon. Subjects were trained to discriminate 10 mg/kg IM injections of either morphine or dextrorphan from saline injections in a two key drug discrimination procedure in which responding was maintained by food presentation. The dextrorphan-trained birds generalized tol-cyclorphan at 10 mg/kg; naltrexone did not alter thel-cyclorphan dose-response curve for this effect. In the morphine-trained group,l-cyclorphan produced only partial generalization, and naltrexone greatly increased the dose ofl-cyclorphan necessary to produced only These results are consistent with the conclusion that in morphine-trained pigeons the partial generalization tol-cyclorphan is mediated by opioid receptors. Moreover, limited intrinsic efficacy at mu opioid receptors may be the characteristic ofl-cyclorphan that prevents full generalization in morphine-trained pigeons.d-Cyclorphan produced partial generalization in both groups, but the involvement of opioid receptor mechanisms could not be confirmed, as 1 mg/kg naltrexone did not antagonized-cyclorphan in either group. Springer-Verlag, 1992 Cyclorphan nationallicence Naltrexone nationallicence Levorphanol nationallicence Dextrorphan nationallicence Opioid antagonism nationallicence Intrinsic efficacy nationallicence Drug discrimination nationallicence Morphine nationallicence Bertalmio Albert Department of Psychology, University of Michigan, 48109-0626, Ann Arbor, MI, USA aut Woods James Department of Psychology, University of Michigan, 48109-0626, Ann Arbor, MI, USA aut Psychopharmacology Springer-Verlag 106/2(1992-06-01), 189-194 0033-3158 106:2<189 1992 106 213 https://doi.org/10.1007/BF02801971 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02801971 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bertalmio Albert Department of Psychology, University of Michigan, 48109-0626, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Woods James Department of Psychology, University of Michigan, 48109-0626, Ann Arbor, MI, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/2(1992-06-01), 189-194 0033-3158 106:2<189 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer