caa a22 4500 469122188 CHVBK 20180323133142.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02801982 doi (NATIONALLICENCE)springer-10.1007/BF02801982 Effect of 5-HT1A receptor agonists in two models of anxiety after dorsal raphe injection [Elektronische Daten] [Guy Higgins, Brian Jones, Nigel Oakley] The purpose of the present study was two-fold. Firstly, to present a more comprehensive analysis of the disinhibitory effects of 5-HT1A receptor agonists after discrete dorsal raphe (DRN) injections (Higgins et al. 1988). Secondly, the effects of the 5-HT1B receptor agonist CGS12066B and the 5-HT1B/1C agonist mCPP were examined following injection into this nucleus. The increases in social interaction (SI) induced by intra-raphe injections of 8-OH DPAT (0.02-1 μg), buspirone (0.04-0.2 μg), ipsapirone (0.2 μg) and gepirone (0.2-1 μg) under a high light unfamiliar paradigm (HLU) were typically due to increased bout frequency, duration and a higher incidence of sniff, follow, allogroom behaviour. These increases were qualitatively similar to those seen in control animals tested under low light/familiar (LLF) conditions, thus supporting the belief that the drug-induced increases in SI reflected decreases in anxiety. Furthermore, at doses effective under the HLU condition, 8-OH DPAT, buspirone and gepirone failed to modify SI under conditions of minimal suppression (LLF paradigm). At doses which significantly increased punished responding in a water-lick conflict test 8-OH DPAT, ipsapirone and gepirone tended to also increase unpunished rates of drinking. However, in drug untreated rats, prior habituation to the test apparatus also increased unpunished drinking, suggesting some neophobia-induced suppression. At a comparatively high dose, the 5-HT1B agonist CGS12066B (2.5 μg), but not the putative 5-HT1B/1c agonist mCPP (0.5-12.5 μg), increased SI under the HLU condition. Considered along-side the other compounds described in this report, the relative potency of CGS12066B may be reflective of a 5-HT1A receptor interaction. Together, these data support the proposal that the DRN is an important site through wich 5-HT1A receptor agonists express their anxiolytic actions. Springer-Verlag, 1992 5-HT1A receptors nationallicence Dorsal raphe nucleus (DRN) nationallicence Social interaction nationallicence Water-lick conflict nationallicence 8-OH DPAT nationallicence Buspirone nationallicence Gepirone nationallicence Ipsapirone nationallicence CGS12066B nationallicence mCPP nationallicence Higgins Guy Department of Neuropharmacology, Glaxo Group Research Ltd., SG12 0DP, Ware, Herts, UK aut Jones Brian Department of Neuropharmacology, Glaxo Group Research Ltd., SG12 0DP, Ware, Herts, UK aut Oakley Nigel Department of Neuropharmacology, Glaxo Group Research Ltd., SG12 0DP, Ware, Herts, UK aut Psychopharmacology Springer-Verlag 106/2(1992-06-01), 261-267 0033-3158 106:2<261 1992 106 213 https://doi.org/10.1007/BF02801982 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02801982 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Higgins Guy Department of Neuropharmacology, Glaxo Group Research Ltd., SG12 0DP, Ware, Herts, UK aut NATIONALLICENCE 700 1- Jones Brian Department of Neuropharmacology, Glaxo Group Research Ltd., SG12 0DP, Ware, Herts, UK aut NATIONALLICENCE 700 1- Oakley Nigel Department of Neuropharmacology, Glaxo Group Research Ltd., SG12 0DP, Ware, Herts, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/2(1992-06-01), 261-267 0033-3158 106:2<261 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer