caa a22 4500 46912220X CHVBK 20180323133142.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02801972 doi (NATIONALLICENCE)springer-10.1007/BF02801972 Biotelemetric investigation of morphine's thermic and kinetic effects in rats [Elektronische Daten] [Richard Dafters, Pauline Taggart] A biotelemetric procedure was used to investigate the thermic and kinetic responses of rats to a range of doses (0.0-30.0 mg/kg) of morphine sulphate. Both responses demonstrated a biphasic dose-response pattern, with depressant effects (hypothermia and hypokinesis) predominant at high doses, and excitatory effects (hyperthermia and hyperkinesis) predominant at low doses. The time-courses of the thermic and kinetic responses were found to be uncorrelated. With repeated doses of morphine, the depressant effects were attenuated (tolerance) while the excitatory effects were augmented (sensitization). These results are interpreted in the light of current views of opiate function. The value of biotelemetry as a means of avoiding the confounding effects of drug-induced thermic responses and thermic responses induced by stressful temperature-assessment procedures is discussed. Springer-Verlag, 1992 Morphine effects nationallicence Body temperature nationallicence Activity nationallicence Biotelemetry nationallicence Dafters Richard Psychology Department, Glasgow University, Adam Smith Building, G12 8RT, Glasgow, UK aut Taggart Pauline Psychology Department, Glasgow University, Adam Smith Building, G12 8RT, Glasgow, UK aut Psychopharmacology Springer-Verlag 106/2(1992-06-01), 195-201 0033-3158 106:2<195 1992 106 213 https://doi.org/10.1007/BF02801972 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02801972 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dafters Richard Psychology Department, Glasgow University, Adam Smith Building, G12 8RT, Glasgow, UK aut NATIONALLICENCE 700 1- Taggart Pauline Psychology Department, Glasgow University, Adam Smith Building, G12 8RT, Glasgow, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/2(1992-06-01), 195-201 0033-3158 106:2<195 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer