caa a22 4500 469122269 CHVBK 20180323133142.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02801980 doi (NATIONALLICENCE)springer-10.1007/BF02801980 Effects of bupropion on core body temperature of mice [Elektronische Daten] [Mohammed-Reza Zarrindast, Farshid Abolfathi-Araghi] The effects of bupropion on core body temperature of intact or reserpinized mice were studied. Intraperitoneal (IP) administration of bupropion to mice induced a dose-dependent hypothermia. The response of bupropion was decreased by the D-2 antagonist sulpiride or pimozide, but not by the D-1 antagonist SCH 23390, antimuscarinic drug atropine, α-adrenergic blocker phenoxybenzimine, β-adrenergic antagonist propranolol or antiserotonergic methergoline. Reserpine induced hypothermia, which was reversed by bupropion administration. The reversal response of bupropion was reduced by propranolol, but not sulpiride, SCH 23390, phenoxybenzamine, atropine or methergoline. It is concluded that bupropion-induced hypothermia may be mediated through D-2 receptor activation, while the reversal of reserpine-induced hypothermia by bupropion may be exerted through β-adrenergic stimulation. Springer-Verlag, 1992 Bupropion nationallicence Temperature nationallicence Sulpiride nationallicence Pimozide nationallicence SCH 23390 nationallicence Reserpine nationallicence Phenoxybenzamine nationallicence Propranolol nationallicence Atropine nationallicence Methergoline nationallicence Mice nationallicence Zarrindast Mohammed-Reza Department of Pharmacology, Medical Faculty, University of Tehran, Tehran, Iran aut Abolfathi-Araghi Farshid Department of Pharmacology, Medical Faculty, University of Tehran, Tehran, Iran aut Psychopharmacology Springer-Verlag 106/2(1992-06-01), 248-252 0033-3158 106:2<248 1992 106 213 https://doi.org/10.1007/BF02801980 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02801980 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zarrindast Mohammed-Reza Department of Pharmacology, Medical Faculty, University of Tehran, Tehran, Iran aut NATIONALLICENCE 700 1- Abolfathi-Araghi Farshid Department of Pharmacology, Medical Faculty, University of Tehran, Tehran, Iran aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/2(1992-06-01), 248-252 0033-3158 106:2<248 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer