caa a22 4500 469122498 CHVBK 20180323133143.0 cr unu---uuuuu 170328e19921101xx s 000 0 eng 10.1007/BF02368610 doi (NATIONALLICENCE)springer-10.1007/BF02368610 Spatial variation of aortic wall oxygen diffusion coefficient from transient polarographic measurements [Elektronische Daten] [Donald Buerk, Thomas Goldstick] Polarographic current transients following a voltage step (turn-on transient) were measured with bare cathodes (25 μm diameter) and shallowly recessed oxygen microelectrodes (<5μm diameter). Except for the initial part of the current transient, the experimental measurements were in excellent agreement with simple models in the literature, which predict an inverse relationship with $$\sqrt t $$ . Turn-on transients were measured in aqueous solutions with known physical properties, and in aortic wall tissue from three different species (n=6 rabbits, n=3 dogs, and n=1 miniature pig). Oxygen diffusion coefficients (D) were determinedin vitro by comparing time constants measured by the same microelectrode in saline and in strips of aortic wall tissue at 37°C. On the inner side (endothelium and intima) of the aorta, D averaged (±S.E.) 7.0 (±0.8)×10−6 cm2/s in 6 rabbits, 6.4 (±1.0)×10−6 cm2/s in 3 dogs, and was 4.6×10−6 cm2/s in the pig. On the adventitial side, D was 9.5×10−6 cm2/s in 1 rabbit, 11.4 (±1.2)×10−6 cm2/s in 3 dogs, and 8.1×10−6 cm2/s in the pig. For every aortic strip on which D was measured from both sides, D for the inner wall was always lower, overall by a little more than one third (p<0.001). The lower D on the endothelial side may limit oxygen transport to the vascular wall and play a role in atherogenesis. Pergamon Press Ltd., 1992 Aortic wall nationallicence Current transient nationallicence Oxygen diffusion coefficient nationallicence Oxygen tension nationallicence Polarographic oxygen electrode nationallicence Buerk Donald Department of Ophthalmology Scheie Eye Institute, University of Pennsylvania, 19104-6068, Philadelphia, PA aut Goldstick Thomas Department of Chemical Engineering, Northwestern University, Evanston, IL aut Annals of Biomedical Engineering Kluwer Academic Publishers 20/6(1992-11-01), 629-646 0090-6964 20:6<629 1992 20 10439 https://doi.org/10.1007/BF02368610 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02368610 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Buerk Donald Department of Ophthalmology Scheie Eye Institute, University of Pennsylvania, 19104-6068, Philadelphia, PA aut NATIONALLICENCE 700 1- Goldstick Thomas Department of Chemical Engineering, Northwestern University, Evanston, IL aut NATIONALLICENCE 773 0- Annals of Biomedical Engineering Kluwer Academic Publishers 20/6(1992-11-01), 629-646 0090-6964 20:6<629 1992 20 10439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer