caa a22 4500 469122803 CHVBK 20180323133143.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02368138 doi (NATIONALLICENCE)springer-10.1007/BF02368138 A pore transport model for pulmonary alveolar epithelium [Elektronische Daten] [T. Chandra, I. Miller, D. Yeates] Hydrodynamic heteropore flow models for transport of solutes across alveolar epithelial tissue have been developed. A two-size cylindrical pore model and a similar parallel-plate model were formulated, tested and used to predict effective pore sizes from literature data on transport in bullfrog, canine and rat lungs. The best fit equivalent pore-size estimates were obtained using a modified, nonlinear least squares procedure, with alveolar surface area to volume ratio (S/V) and small-pore area fraction of total pore area as parameters. Small-pore and large-pore width estimates of 4 nm (84% of total flow area) and 10 nm, respectively, with an average deviation of 20% from experimentally derived permeabilities were obtained from the bullfrog alveolar epithelium parallel-plate pore model (13 solutes, diameters 0.3 to 2.8 nm). The equivalent cylindrical pore model diameter estimates were 5 nm and 10 nm, with small-pore area fraction and percentage deviations similar to the parallel-plate model estimates. Eighty-eight percent of the bulk water driven by a sucrose osmotic gradient was predicted to be transported through the small pores. The rat alveolus parallel-plate pore model (6 solutes) yielded small-pore and large-pore widths of 0.4 nm and 50 nm, respectively. Clearance rate-constant data for dextran macromolecules (3,000 to 250,000 Daltons), using a single parallel-plate pore model, resulted in a pore width estimate of 98 nm for canine alveoli with an average deviation of the predicted rate constants of 18% from literature experimental values. In all cases tested, the parallel-plate pore model predicted lower small-pore size estimates than did the cylindrical pore model, and both models had appreciably smaller percentage deviations from experimental data than previous models. Pergamon Press Ltd., 1992 Hydrodynamic model nationallicence Pore flow nationallicence Membrane transport nationallicence Alveolus nationallicence Epithelium nationallicence Permeability nationallicence Chandra T. Department of Chemical Engineering, Chicago, IL aut Miller I. Department of Medicine, University of Illinois at Chicago, Chicago, IL aut Yeates D. V.A. West Side, 820 South Damen, Chicago, IL aut Annals of Biomedical Engineering Kluwer Academic Publishers 20/4(1992-07-01), 481-494 0090-6964 20:4<481 1992 20 10439 https://doi.org/10.1007/BF02368138 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02368138 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chandra T. Department of Chemical Engineering, Chicago, IL aut NATIONALLICENCE 700 1- Miller I. Department of Medicine, University of Illinois at Chicago, Chicago, IL aut NATIONALLICENCE 700 1- Yeates D. V.A. West Side, 820 South Damen, Chicago, IL aut NATIONALLICENCE 773 0- Annals of Biomedical Engineering Kluwer Academic Publishers 20/4(1992-07-01), 481-494 0090-6964 20:4<481 1992 20 10439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer