caa a22 4500 469122854 CHVBK 20180323133143.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02368171 doi (NATIONALLICENCE)springer-10.1007/BF02368171 A model of ion channel kinetics based on deterministic, chaotic motion in a potential with two local minima [Elektronische Daten] [Larry Liebovitch, Ferenc Czegledy] Models of the gating of ion channels have usually assumed that the switching between the open and closed states is a random process without a mechanistic basis. We explored the properties of a deterministic model of channel gating based on a chaotic dynamic system. The channel is modeled as a nonlinear oscillator, that has a potential function with two minima, which correspond to the stable open and closed states, and is driven by a periodic driving force. The properties of the model are like some properties of single channel data and unlike other properties. The model is like the data in that: the current switches between two well-defined states, this switching is nonperiodic, and there are subconductance states. These subconductance states are subharmonic resonances, due to the nonlinearities in the equation of the model, rather than stable conformational states due to local minima in the potential energy. The model is not like the data in that the current fluctuates too much within in each state and there are sometimes periodic fluctuations within a state. At the present time, the selection of the most appropriate channel model (Markov, chaotic, or other) is not possible, and in addition to chaotic models, other nonlinear models may be suitable. Pergamon Press Ltd, 1992 Ion channel nationallicence Kinetics nationallicence Nonlinear dynamics nationallicence Chaos nationallicence Mathematical model nationallicence Liebovitch Larry Department of Ophthalmology College of Physicians & Surgeons, Columbia University, 630 West 168th Street, 10032, New York, NY aut Czegledy Ferenc Department of Ophthalmology College of Physicians & Surgeons, Columbia University, 630 West 168th Street, 10032, New York, NY aut Annals of Biomedical Engineering Kluwer Academic Publishers 20/5(1992-09-01), 517-531 0090-6964 20:5<517 1992 20 10439 https://doi.org/10.1007/BF02368171 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02368171 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liebovitch Larry Department of Ophthalmology College of Physicians & Surgeons, Columbia University, 630 West 168th Street, 10032, New York, NY aut NATIONALLICENCE 700 1- Czegledy Ferenc Department of Ophthalmology College of Physicians & Surgeons, Columbia University, 630 West 168th Street, 10032, New York, NY aut NATIONALLICENCE 773 0- Annals of Biomedical Engineering Kluwer Academic Publishers 20/5(1992-09-01), 517-531 0090-6964 20:5<517 1992 20 10439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer