caa a22 4500 469122900 CHVBK 20180323133143.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02368519 doi (NATIONALLICENCE)springer-10.1007/BF02368519 Modelling the dynamic ventilatory response to hypoxia in humans [Elektronische Daten] [Denham Ward, Alberg Dahan, Carol Mann] A two-component dynamic model was used to describe the ventilatory response to sustained hypoxia in humans. One component (Xs) represents the stimulating effects of hypoxia and the other component (Xd), the hypoxic ventilatory decline. The total ventilatory response to hypoxia is represented by the sum of the two components. A nonlinearity is included to account for the nonlinear steady-state ventilatory response to hypoxia. A sensitivity analysis of the model indicates that, with a step change in $$F_{ETO_2 }$$ as the input, all the parameters can be estimated from the data except for the nonlinearity. The relative sensitivity of the parameters from the model analysis was confirmed in an experimental study. However, comparing steps into hypoxia versus steps out of hypoxia we found a decrease in the gains of both components. The most likely explanation for the decrease in the gains is that the combination of Xs and Xd is not entirely additive. Other models may be required to completely describe the ventilatory response to inputs more complex than steps. Pergamon Press Ltd., 1992 Ventilation nationallicence Square-wave hypoxic transients nationallicence Sustained hypoxia nationallicence Modelling nationallicence Dynamic end-tidal forcing nationallicence Ward Denham Department of Anesthesiology, University of California, School of Medicine, 90024-1778, Los Angeles, CA aut Dahan Alberg Department of Anesthesiology, University of Leiden, 2300 RC, Leiden, The Netherlands aut Mann Carol Department of Anesthesiology, University of California, School of Medicine, 90024-1778, Los Angeles, CA aut Annals of Biomedical Engineering Kluwer Academic Publishers 20/2(1992-03-01), 181-194 0090-6964 20:2<181 1992 20 10439 https://doi.org/10.1007/BF02368519 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02368519 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ward Denham Department of Anesthesiology, University of California, School of Medicine, 90024-1778, Los Angeles, CA aut NATIONALLICENCE 700 1- Dahan Alberg Department of Anesthesiology, University of Leiden, 2300 RC, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Mann Carol Department of Anesthesiology, University of California, School of Medicine, 90024-1778, Los Angeles, CA aut NATIONALLICENCE 773 0- Annals of Biomedical Engineering Kluwer Academic Publishers 20/2(1992-03-01), 181-194 0090-6964 20:2<181 1992 20 10439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer