caa a22 4500 469122994 CHVBK 20180323133144.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02368521 doi (NATIONALLICENCE)springer-10.1007/BF02368521 Attenuation of pathological tremors by functional electrical stimulation I: Method [Elektronische Daten] [Arthur Prochazka, Josef Elek, Manouchehr Javidan] In this study we explored the possibility of suppressing pathological tremors using closed-loop functional electrical stimulation (FES) to activate the tremorogenic muscles out-of-phase. A displacement signal monitored with a transducer was filtered so as to be "tuned” to the tremor frequency at the wrist or elbow. The filtered signal was used to amplitude-modulate the electrical stimulation. The design process was based on measurements of the open-loop frequency response characteristics of the forearm and hand to stimulation of the elbow and wrist flexors and extensors in a number of subjects. These data allowed us to identify closed-loop configurations, which attenuated 2-5 Hz tremors substantially, while only minimally attenuating functional movements in the 0-1 Hz range. There was a fairly delicate balance between efficacy and the risk of instability. However, designs were identified that offered enough tremor suppression and adequate immunity to muscle/load variations for the technique to be considered seriously for clinical application. Pergamon Press Ltd., 1992 Tremor nationallicence Electrical stimulation nationallicence Prochazka Arthur Divisions of Neuroscience and Neurology Room 507, Heritage Building, University of Alberta, T6G 2S2, Edmonton, Alberta, Canada aut Elek Josef Neurologische Klinik der Universität Bonn, Germany aut Javidan Manouchehr Divisions of Neuroscience and Neurology Room 507, Heritage Building, University of Alberta, T6G 2S2, Edmonton, Alberta, Canada aut Annals of Biomedical Engineering Kluwer Academic Publishers 20/2(1992-03-01), 205-224 0090-6964 20:2<205 1992 20 10439 https://doi.org/10.1007/BF02368521 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02368521 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Prochazka Arthur Divisions of Neuroscience and Neurology Room 507, Heritage Building, University of Alberta, T6G 2S2, Edmonton, Alberta, Canada aut NATIONALLICENCE 700 1- Elek Josef Neurologische Klinik der Universität Bonn, Germany aut NATIONALLICENCE 700 1- Javidan Manouchehr Divisions of Neuroscience and Neurology Room 507, Heritage Building, University of Alberta, T6G 2S2, Edmonton, Alberta, Canada aut NATIONALLICENCE 773 0- Annals of Biomedical Engineering Kluwer Academic Publishers 20/2(1992-03-01), 205-224 0090-6964 20:2<205 1992 20 10439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer