caa a22 4500 469127325 CHVBK 20180323133154.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02359607 doi (NATIONALLICENCE)springer-10.1007/BF02359607 Therapeutic activity of isometamidium chloride in Boran cattle against a tsetse-transmitted clone of Trypanosoma congolense with a low level of drug resistance [Elektronische Daten] [I. Sutherland, V. Codjia, S. Moloo, P. Holmes, A. Peregrine] Summary: Experiments were conducted with a clone ofTrypanosoma congolense, IL 3580, which exhibited a low level of resistance to isometanidium chloride. Five cattle were treated intramuscularly with isometamidium chloride at a dose rate of 0·5mgkg−1 body weight (BW) and challenged 28 days later with 5Glossina morsitans centralis infected withT. congolense IL 3580. All 5 cattle and 15 untreated steers challenged on the same day became parasitaemic by day 15 post-infection. Thus, at a dose of 0·5 mg kg−1 BW, the prophylactic action of isometamidium chloride did not extend to 28 days following treatment. Subsequently, the 20 steers were divided into 4 groups of 5 animals each and treated with isometamidium chloride at one of the following dose rates; 0·5 or 1·0 mg kg−1 BW intramuscularly and 0·5 or 1·0 mg kg−1 BW intravenously (Groups A, B, C and D, respectively). Group A consisted of the 5 animals that had previously been treated with isometamidium chloride. Animals relapsed in all groups except those in Group B, treated intramuscularly with isometamidium chloride at a dose of 1·0 mg kg−1 BW. Four of the 5 animals in Group A, treated intramuscularly with isometamidium chloride at a dose of 0·5 mg kg−1 BW relapsed following a mean interval of 16 days post-treatment. Similarly, infections in all animals in Groups C and D, given intravenous injections of isometamidium chloride at a dose of 0·5 and 1·0mg kg−1 BW, respectively, were not eliminated as a result of treatment. The mean intervals to first detection of parasitaemia in these 2 groups following treatment were 14 and 20 days, respectively. The results therefore indicate that intravenous administration of isometamidium chloride does not enhance the drug's therapeutic efficacy in the treatment of aT. congolense clone which expresses a low, but significant, level of resistance to isometamidium. Centre for Tropical Veterinary Medicine, University of Edinburgh, 1992 Sutherland I. University of Glasgow veterinary School, Bearsden Road, G61 1QH, Glasgow, Scotland, UK aut Codjia V. International Laboratory for Research on Animal Diseases (ILRAD), PO Box 30709, Nairobi, Kenya aut Moloo S. International Laboratory for Research on Animal Diseases (ILRAD), PO Box 30709, Nairobi, Kenya aut Holmes P. University of Glasgow veterinary School, Bearsden Road, G61 1QH, Glasgow, Scotland, UK aut Peregrine A. International Laboratory for Research on Animal Diseases (ILRAD), PO Box 30709, Nairobi, Kenya aut Tropical Animal Health and Production Kluwer Academic Publishers 24/3(1992-09-01), 157-163 0049-4747 24:3<157 1992 24 11250 https://doi.org/10.1007/BF02359607 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02359607 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sutherland I. University of Glasgow veterinary School, Bearsden Road, G61 1QH, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- Codjia V. International Laboratory for Research on Animal Diseases (ILRAD), PO Box 30709, Nairobi, Kenya aut NATIONALLICENCE 700 1- Moloo S. International Laboratory for Research on Animal Diseases (ILRAD), PO Box 30709, Nairobi, Kenya aut NATIONALLICENCE 700 1- Holmes P. University of Glasgow veterinary School, Bearsden Road, G61 1QH, Glasgow, Scotland, UK aut NATIONALLICENCE 700 1- Peregrine A. International Laboratory for Research on Animal Diseases (ILRAD), PO Box 30709, Nairobi, Kenya aut NATIONALLICENCE 773 0- Tropical Animal Health and Production Kluwer Academic Publishers 24/3(1992-09-01), 157-163 0049-4747 24:3<157 1992 24 11250 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer