caa a22 4500 469127732 CHVBK 20180323133155.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02356946 doi (NATIONALLICENCE)springer-10.1007/BF02356946 Isolation of drug-resistant strains of Trypanosoma congolense from the Lower Shabelle Region of southern Somalia [Elektronische Daten] [O. Ainanshe, F. Jennings, P. Holmes] Summary: Drug resistance by pathogenic trypanosomes in Somali livestock has been suspected for some time but there have been few attempts to examine this problem in detail. Field isolations from two areas in the Lower Shabelle Region were obtained by injecting blood from trypanosome infected cattle into a recipient calf. Once the calf became parasitaemic it was treated with a standard dose of isometamidium chloride (Samorin, RMB) at 0·5 mg/kg. When a subsequent relapse infection developed, indicative of drug resistance, blood was taken and injected into groups of cattle and mice and these were treated with a range of doses of isometamidium chloride and diminazene aceturate (Berenil, Hoechst AC) to determine the dagree of drug resistance. Both isolates showed remarkably high levels of drug resistance to both isometamidium chloride and diminazene aceturate, with minimum curative doses in cattle of >2·0 mg/kg and 7·5 mg/kg for the two drugs respectively. Minimum curative doses in mice were approximately ten-fold those in cattle. Fortunately there have been a very few reports from Africa of such high levels of resistance ofTrypanosoma congolense to this normal "sanative pair” of drugs. The results indicate that drug resistance could be an important constrain on the use of trypanocidal drugs to control trypanosomosis in Somalia. Centre for Tropical Veterinary Medicine, 1992 Ainanshe O. N.T.T.C.P., PO Box 6956, Somalia aut Jennings F. University of Glasgow Veterinary School, G61 1QH, Glasgow, UK aut Holmes P. University of Glasgow Veterinary School, G61 1QH, Glasgow, UK aut Tropical Animal Health and Production Kluwer Academic Publishers 24/2(1992-06-01), 65-73 0049-4747 24:2<65 1992 24 11250 https://doi.org/10.1007/BF02356946 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02356946 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ainanshe O. N.T.T.C.P., PO Box 6956, Somalia aut NATIONALLICENCE 700 1- Jennings F. University of Glasgow Veterinary School, G61 1QH, Glasgow, UK aut NATIONALLICENCE 700 1- Holmes P. University of Glasgow Veterinary School, G61 1QH, Glasgow, UK aut NATIONALLICENCE 773 0- Tropical Animal Health and Production Kluwer Academic Publishers 24/2(1992-06-01), 65-73 0049-4747 24:2<65 1992 24 11250 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer