caa a22 4500 469128054 CHVBK 20180323133156.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF01809860 doi (NATIONALLICENCE)springer-10.1007/BF01809860 New insights on the comma-less theory [Elektronische Daten] [Enrique Merino, Paulina Balbás, Francisco Bolivar] The comma-less hypothesis represents a theoretical effort to describe one of the steps in the early evolution of the translation apparatus. This hypothesis emphasizes the advantages that a RNY coding pattern would have provided in a primitive RNA adaptor-catalyst system. This theory has been debated for years, both in conceptual and statistical terms, and no consensus about its validity has been ascertained. In this work, a statistical model refuting this theory was reconsidered. This new approach eliminates the bias due to the absence of stop codons in the open reading frame, and to the amino acid composition of bacterial genes. The results obtained support the biological significance of the RNY coding pattern. Kluwer Academic Publishers, 1992 Merino Enrique Department of Molecular Biology, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Mexico aut Balbás Paulina Department of Molecular Biology, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Mexico aut Bolivar Francisco Department of Molecular Biology, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Mexico aut Origins of life and evolution of the biosphere Kluwer Academic Publishers 21/4(1992-07-01), 251-254 0169-6149 21:4<251 1992 21 11084 https://doi.org/10.1007/BF01809860 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01809860 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Merino Enrique Department of Molecular Biology, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Mexico aut NATIONALLICENCE 700 1- Balbás Paulina Department of Molecular Biology, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Mexico aut NATIONALLICENCE 700 1- Bolivar Francisco Department of Molecular Biology, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Mexico aut NATIONALLICENCE 773 0- Origins of life and evolution of the biosphere Kluwer Academic Publishers 21/4(1992-07-01), 251-254 0169-6149 21:4<251 1992 21 11084 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer