caa a22 4500 469128305 CHVBK 20180323133156.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF01810856 doi (NATIONALLICENCE)springer-10.1007/BF01810856 Experimental studies on the origin of the genetic code and the process of protein synthesis: A review update [Elektronische Daten] Invited review [James Lacey Jr., Nalinie Wickramasinghe, Gary Cook] This article is an update of our earlier review (Lacey and Mullins, 1983) in this journal on the origin of the genetic code and the process of protein synthesis. It is our intent to discuss only experimental evidence published since then although there is the necessity to mention the old enough to place the new in context. We do not include theoretical nor hypothetical treatments of the code or protein synthesis. Relevant data regarding the evolution of tRNAs and the recognition of tRNAs by aminoacyl-tRNA-synthetases are discussed. Our present belief is that the code arose based on a core of early assignments which were made on a physico-chemical and anticodonic basis and this was expanded with new assignments later. These late assignments do not necessarily show an amino acid-anticodon relatedness. In spite of the fact that most data suggest a code origin based on amino acid-anticodon relationships, some new data suggesting preferential binding of Arg to its codons are discussed. While information regarding coding is not increasing very rapidly, information regarding the basic chemistry of the process of protein synthesis has increased significantly, principally relating to aminoacylation of mono- and polyribonucleotides. Included in those studies are several which show stereoselective reactions of L-amino acids with nucleotides having D-sugars. Hydrophobic interactions definitely play a role in the preferences which have been observed. Kluwer Academic Publishers, 1992 Lacey Jr. James Department of Biochemistry, University of Alabama at Birmingham, 35294, Birminghanm, AL, USA aut Wickramasinghe Nalinie Department of Biochemistry, University of Alabama at Birmingham, 35294, Birminghanm, AL, USA aut Cook Gary Department of Biochemistry, University of Alabama at Birmingham, 35294, Birminghanm, AL, USA aut Origins of life and evolution of the biosphere Kluwer Academic Publishers 22/5(1992-09-01), 243-275 0169-6149 22:5<243 1992 22 11084 https://doi.org/10.1007/BF01810856 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01810856 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lacey Jr James Department of Biochemistry, University of Alabama at Birmingham, 35294, Birminghanm, AL, USA aut NATIONALLICENCE 700 1- Wickramasinghe Nalinie Department of Biochemistry, University of Alabama at Birmingham, 35294, Birminghanm, AL, USA aut NATIONALLICENCE 700 1- Cook Gary Department of Biochemistry, University of Alabama at Birmingham, 35294, Birminghanm, AL, USA aut NATIONALLICENCE 773 0- Origins of life and evolution of the biosphere Kluwer Academic Publishers 22/5(1992-09-01), 243-275 0169-6149 22:5<243 1992 22 11084 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer