caa a22 4500 469128348 CHVBK 20180323133156.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00573474 doi (NATIONALLICENCE)springer-10.1007/BF00573474 Diabetic cardiorenal syndrome: insights into its pathogenesis [Elektronische Daten] [Gian Viberti, Jeannie Yip, Kenneth Earle] A subset of diabetic patients develops renal or cardiovascular complications: the cardiorenal syndrome. A constellation of risk factors coexist and appear to interact. Raised arterial pressure, poor metabolic control and dyslipidaemia are already present at the stage of microalbuminuria, which in itself is associated with significant glomerular pathology. Family histories of diabetic nephropathy, hypertension or cardiovascular disease are all significantly related to the development of proteinuria in the diabetic proband. The presence of elevated red cell sodium-lithium countertransport increases the risk of proteinuria by approximately fourfold and is related to reduced insulin sensitivity, a phenomenon that itself is linked to cardiovascular risk in the general population. Susceptibility factors, most probably genetic, which are associated with a familial disposition to cardiovacular disease therefore appear crucial for the development of the cardiorenal syndrome of diabetes. Springer-Verlag, 1992 Diabetic renal disease nationallicence Diabetic cardiovascular complications nationallicence Na+/Li+ countertransport nationallicence Familial clustering nationallicence Insulin resistance nationallicence Viberti Gian Unit for Metabolic Medicine, United Medical and Dental Schools, Guy's Hospital, 4th Floor, Hunts House, SE1 9RT, London, UK aut Yip Jeannie Unit for Metabolic Medicine, United Medical and Dental Schools, Guy's Hospital, 4th Floor, Hunts House, SE1 9RT, London, UK aut Earle Kenneth Unit for Metabolic Medicine, United Medical and Dental Schools, Guy's Hospital, 4th Floor, Hunts House, SE1 9RT, London, UK aut Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 116-118 0940-5429 29:3-4<116 1992 29 592 https://doi.org/10.1007/BF00573474 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00573474 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Viberti Gian Unit for Metabolic Medicine, United Medical and Dental Schools, Guy's Hospital, 4th Floor, Hunts House, SE1 9RT, London, UK aut NATIONALLICENCE 700 1- Yip Jeannie Unit for Metabolic Medicine, United Medical and Dental Schools, Guy's Hospital, 4th Floor, Hunts House, SE1 9RT, London, UK aut NATIONALLICENCE 700 1- Earle Kenneth Unit for Metabolic Medicine, United Medical and Dental Schools, Guy's Hospital, 4th Floor, Hunts House, SE1 9RT, London, UK aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 116-118 0940-5429 29:3-4<116 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer