caa a22 4500 469128356 CHVBK 20180323133156.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00573488 doi (NATIONALLICENCE)springer-10.1007/BF00573488 Insulin resistance, hypertension and cellular ion transport systems [Elektronische Daten] [Anna Solini, Ralph DeFronzo] Much epidemiological, physiological and biochemical evidence links insulin resistance and hyperinsulinaemia to the pathogenesis of hypertension in some metabolic diseases such as obesity and type 2 (non-insulin-depedent) diabetes mellitus. Insulin resistance per se, by altering the energy needs of the cell, by causing a shift from glucose to lipid metabolism, or by some other incompletely defined mechanisms, could be responsible for the development of hypertension. It is also possible that hyperinsulinaemia, by acting on the vascular tree, leads to an increase in blood pressure. Moreover, insulin has been shown to augment renal sodium reabsorption, to stimulate the sympathetic nervous system, to influence atrial natriuretic peptide release and the renin-angiotensin-aldosterone system and to activate a number of sodium pumps which are present in all cell membranes, including vascular smooth muscle cells. Insulin can also directly stimulate cell growth. All these mechanisms, in various combinations, with the concurrence of some genetic factors, could lead to the development of the association between hypertension and abnormalities in glucose metabolism. Springer-Verlag, 1992 Hyperinsulinaemia nationallicence Glucose metabolism nationallicence Hypertension nationallicence Ion pumps-ANP nationallicence Solini Anna Istituto di Medicina, University of Padua, Italy aut DeFronzo Ralph Diabetes Division, University of Texas, 7703 Floyd Curl Drive, 78284, San Antonio, Texas, USA aut Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 196-200 0940-5429 29:3-4<196 1992 29 592 https://doi.org/10.1007/BF00573488 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00573488 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Solini Anna Istituto di Medicina, University of Padua, Italy aut NATIONALLICENCE 700 1- DeFronzo Ralph Diabetes Division, University of Texas, 7703 Floyd Curl Drive, 78284, San Antonio, Texas, USA aut NATIONALLICENCE 773 0- Acta Diabetologica Springer-Verlag 29/3-4(1992-09-01), 196-200 0940-5429 29:3-4<196 1992 29 592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer